RATIONALE AND OBJECTIVES: A model of chronic noncommunicating hydrocephalus in canines was developed, and gadolinium-DTPA (Gd-DTPA)-enhanced magnetic resonance imaging, physiologic and morphologic studies were performed to investigate transventricular absorption of cerebrospinal fluid. METHODS: Chronic hydrocephalus was induced in 12 mongrel dogs by injection of a silastic mixture into the prepontine cisterns. Ventricular pressure was measured during the development of hydrocephalus, and lateral ventriculo-ventricular perfusions with Gd-DTPA were performed under controlled conditions during serial magnetic resonance imaging studies. RESULTS: Hydrocephalus developed over an average of 129 +/- 24 days after induction, and the intraventricular pressure increased from an initial level of 14 +/- 4 cm H2O to a stabilized plateau of 25 +/- 5 cm H2O. Increased signal intensity in the brain matter, as seen on magnetic resonance images of chronic hydrocephalic dogs perfused with Gd-DTPA in the lateral ventricles, was consistent with the presence of the contrast agent in the periventricular extracellular space. This increased signal intensity was not observed in control animals. CONCLUSIONS: These results provide direct evidence of transventricular absorption in chronic hydrocephalus.
RATIONALE AND OBJECTIVES: A model of chronic noncommunicating hydrocephalus in canines was developed, and gadolinium-DTPA (Gd-DTPA)-enhanced magnetic resonance imaging, physiologic and morphologic studies were performed to investigate transventricular absorption of cerebrospinal fluid. METHODS: Chronic hydrocephalus was induced in 12 mongrel dogs by injection of a silastic mixture into the prepontine cisterns. Ventricular pressure was measured during the development of hydrocephalus, and lateral ventriculo-ventricular perfusions with Gd-DTPA were performed under controlled conditions during serial magnetic resonance imaging studies. RESULTS:Hydrocephalus developed over an average of 129 +/- 24 days after induction, and the intraventricular pressure increased from an initial level of 14 +/- 4 cm H2O to a stabilized plateau of 25 +/- 5 cm H2O. Increased signal intensity in the brain matter, as seen on magnetic resonance images of chronic hydrocephalic dogs perfused with Gd-DTPA in the lateral ventricles, was consistent with the presence of the contrast agent in the periventricular extracellular space. This increased signal intensity was not observed in control animals. CONCLUSIONS: These results provide direct evidence of transventricular absorption in chronic hydrocephalus.
Authors: M Tullberg; J E Månsson; P Fredman; A Lekman; K Blennow; R Ekman; L E Rosengren; M Tisell; C Wikkelsø Journal: J Neurol Neurosurg Psychiatry Date: 2000-07 Impact factor: 10.154
Authors: James P McAllister; Michael R Talcott; Albert M Isaacs; Sarah H Zwick; Maria Garcia-Bonilla; Leandro Castaneyra-Ruiz; Alexis L Hartman; Ryan N Dilger; Stephen A Fleming; Rebecca K Golden; Diego M Morales; Carolyn A Harris; David D Limbrick Journal: Fluids Barriers CNS Date: 2021-11-08
Authors: Daniela Farke; Malgorzata Kolecka; Adriana Czerwik; Marcin Wrzosek; Sebastian Schaub; Martin Kramer; Klaus Failing; Martin Jürgen Schmidt Journal: J Vet Intern Med Date: 2020-09-12 Impact factor: 3.333