| Literature DB >> 8175201 |
J C Gerlach1, K Klöppel, C Müller, N Schnoy, M D Smith, P Neuhaus.
Abstract
Utilizing a modified culture technique for hepatocytes, a high performance suspension culture is possible in which hepatocytes spontaneously form cell aggregates. The aggregates of 20-100 cells have been histologically confirmed to hold a three-dimensional structure, they show a long-term external metabolism and a survival time comparable with standard adhesion cultures. This technique has several advantages in the construction of large scale bioreactors for hybrid liver support systems.Mesh：
Year: 1993 PMID： 8175201
Source DB: PubMed Journal: Int J Artif Organs ISSN： 0391-3988 Impact factor: 1.595