Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration.

Recent studies indicate that migration of neurons from their place of origin to their final destination requires the orchestration of multiple molecular events, including the selection of a pathway by cell recognition receptors, the formation of adhesive interactions with cellular and extracellular substrates through multiple adhesion molecules and the activation of specific ion channels and receptors that provide second messenger mediated signals for the diverse cellular mechanisms involved in cell motility. New approaches allow for the examination of the role of individual molecular components that mediate these processes.