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Literature DB >> 8171027

Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.

F A Wilson¹, S P O'Scalaidhe, P S Goldman-Rakic.

Abstract

The responses of putative gamma-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that gamma-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with gamma-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of gamma-aminobutyratergic mechanisms in cognition.

Entities: Chemical

Mesh：

Substances：
gamma-Aminobutyric Acid

Year: 1994 PMID： 8171027 PMCID： PMC43712 DOI： 10.1073/pnas.91.9.4009

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

Review 1. Intrinsic firing patterns of diverse neocortical neurons.

Authors: B W Connors; M J Gutnick
Journal: Trends Neurosci Date: 1990-03 Impact factor: 13.837

2. Context-dependent responses of primate nucleus basalis neurons in a go/no-go task.

Authors: R T Richardson; M R DeLong
Journal: J Neurosci Date: 1990-08 Impact factor: 6.167

3. A functional microcircuit for cat visual cortex.

Authors: R J Douglas; K A Martin
Journal: J Physiol Date: 1991 Impact factor: 5.182

4. Neuronal responses related to reinforcement in the primate basal forebrain.

Authors: F A Wilson; E T Rolls
Journal: Brain Res Date: 1990-02-19 Impact factor: 3.252

5. Cortical neuronal mechanisms in flutter-vibration studied in unanesthetized monkeys. Neuronal periodicity and frequency discrimination.

Authors: V B Mountcastle; W H Talbot; H Sakata; J Hyvärinen
Journal: J Neurophysiol Date: 1969-05 Impact factor: 2.714

6. Dissociation of object and spatial processing domains in primate prefrontal cortex.

Authors: F A Wilson; S P Scalaidhe; P S Goldman-Rakic
Journal: Science Date: 1993-06-25 Impact factor: 47.728

7. Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe.

Authors: C Cavada; P S Goldman-Rakic
Journal: J Comp Neurol Date: 1989-09-22 Impact factor: 3.215

8. Groupings of nonpyramidal and pyramidal cells with specific physiological and morphological characteristics in rat frontal cortex.

Authors: Y Kawaguchi
Journal: J Neurophysiol Date: 1993-02 Impact factor: 2.714

9. GABA shapes a topographic organization of response latency in the mustache bat's inferior colliculus.

Authors: T J Park; G D Pollak
Journal: J Neurosci Date: 1993-12 Impact factor: 6.167

10. Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: evidence for the involvement of both dopaminergic and GABAergic components.

Authors: S Pirot; R Godbout; J Mantz; J P Tassin; J Glowinski; A M Thierry
Journal: Neuroscience Date: 1992-08 Impact factor: 3.590

89 in total

1. Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate.

Authors: R Levy; P S Goldman-Rakic
Journal: J Neurosci Date: 1999-06-15 Impact factor: 6.167

2. Emergent oscillations in a realistic network: the role of inhibition and the effect of the spatiotemporal distribution of the input.

Authors: Q Pauluis; S N Baker; E Olivier
Journal: J Comput Neurosci Date: 1999-01 Impact factor: 1.621

Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.

Review 1. Intrinsic firing patterns of diverse neocortical neurons.

2. Context-dependent responses of primate nucleus basalis neurons in a go/no-go task.

3. A functional microcircuit for cat visual cortex.

4. Neuronal responses related to reinforcement in the primate basal forebrain.

5. Cortical neuronal mechanisms in flutter-vibration studied in unanesthetized monkeys. Neuronal periodicity and frequency discrimination.

6. Dissociation of object and spatial processing domains in primate prefrontal cortex.

7. Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe.

8. Groupings of nonpyramidal and pyramidal cells with specific physiological and morphological characteristics in rat frontal cortex.

9. GABA shapes a topographic organization of response latency in the mustache bat's inferior colliculus.

10. Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: evidence for the involvement of both dopaminergic and GABAergic components.

1. Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate.

2. Emergent oscillations in a realistic network: the role of inhibition and the effect of the spatiotemporal distribution of the input.

3. Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition.

4. The physiological role of 5-HT2A receptors in working memory.

5. Prefrontal microcircuits: membrane properties and excitatory input of local, medium, and wide arbor interneurons.

6. Coding specificity in cortical microcircuits: a multiple-electrode analysis of primate prefrontal cortex.

7. Activity of different classes of neurons of the motor cortex during locomotion.

8. Roles of monkey premotor neuron classes in movement preparation and execution.

9. Alteration by p11 of mGluR5 localization regulates depression-like behaviors.

10. Flexibility of sensory representations in prefrontal cortex depends on cell type.