Literature DB >> 8169792

Potential radioprotective agents. 1. Homologs of melatonin.

R T Blickenstaff1, S M Brandstadter, S Reddy, R Witt.   

Abstract

Homologs of melatonin were prepared by acylation of 5-methoxytryptamine with the appropriate acid chloride or anhydride. The products were administered as solutions or suspensions in soybean oil by ip injection to mice 30 min prior to irradiation with 950 cGy of 6 mV photons. Protection was achieved with all compounds, survival rate being maximal for mice treated with the hexanoic amide 5 and the octanoic amide 6.

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Year:  1994        PMID: 8169792     DOI: 10.1002/jps.2600830220

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  8 in total

1.  Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation.

Authors:  M Karbownik; R J Reiter; W Qi; J J Garcia; D X Tan; L C Manchester
Journal:  Mol Cell Biochem       Date:  2000-08       Impact factor: 3.396

2.  Protective effect of an antithyroid compound against γ-radiation-induced damage in human colon cancer cells.

Authors:  Marina Perona; Maria A Dagrosa; Romina Pagotto; Mariana Casal; Omar Pignataro; Mario A Pisarev; Guillermo J Juvenal
Journal:  Radiat Environ Biophys       Date:  2014-05-09       Impact factor: 1.925

3.  Evaluation of the fullerene compound DF-1 as a radiation protector.

Authors:  Aaron P Brown; Eun Joo Chung; Mary Ellen Urick; William P Shield; Anastasia L Sowers; Angela Thetford; Uma T Shankavaram; James B Mitchell; Deborah E Citrin
Journal:  Radiat Oncol       Date:  2010-05-11       Impact factor: 3.481

Review 4.  Radioprotectors and mitigators of radiation-induced normal tissue injury.

Authors:  Deborah Citrin; Ana P Cotrim; Fuminori Hyodo; Bruce J Baum; Murali C Krishna; James B Mitchell
Journal:  Oncologist       Date:  2010

Review 5.  Oral Mucositis: Melatonin Gel an Effective New Treatment.

Authors:  Ahmed Esmat Abdel Moneim; Ana Guerra-Librero; Javier Florido; Ying-Qiang Shen; Beatriz Fernández-Gil; Darío Acuña-Castroviejo; Germaine Escames
Journal:  Int J Mol Sci       Date:  2017-05-07       Impact factor: 5.923

Review 6.  Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.

Authors:  Russel J Reiter; Sergio A Rosales-Corral; Dun-Xian Tan; Dario Acuna-Castroviejo; Lilan Qin; Shun-Fa Yang; Kexin Xu
Journal:  Int J Mol Sci       Date:  2017-04-17       Impact factor: 5.923

7.  Radioprotective effect of melatonin on the cervical spinal cord in irradiated rats.

Authors:  Gholamhassan Haddadi; Alireza Shirazi; Zargham Sepehrizadeh; Seied Rabie Mahdavi; Maryam Haddadi
Journal:  Cell J       Date:  2013-02-20       Impact factor: 2.479

8.  Enhanced anti-angiogenic activity of novel melatonin-like agents.

Authors:  Su Jung Hwang; Yeonghun Jung; Ye-Seul Song; Suryeon Park; Yohan Park; Hyo-Jong Lee
Journal:  J Pineal Res       Date:  2021-05-13       Impact factor: 13.007

  8 in total

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