Literature DB >> 8168985

Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection.

J Sternberg1, N Mabbott, I Sutherland, F Y Liew.   

Abstract

In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

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Year:  1994        PMID： 8168985      PMCID： PMC186483          DOI： 10.1128/iai.62.5.2135-2137.1994

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

1.  Antigenic variation in syringe passaged populations of Trypanosoma (Trypanozoon) brucei. 1. Rationalization of the experimental approach.

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Journal:  Ann Soc Belg Med Trop       Date:  1975

Review 2.  Macrophages as mediators of immunosuppression in murine African trypanosomiasis.

Authors:  B A Askonas
Journal:  Curr Top Microbiol Immunol       Date:  1985       Impact factor: 4.291

Review 3.  Biosynthesis and metabolism of endothelium-derived nitric oxide.

Authors:  L J Ignarro
Journal:  Annu Rev Pharmacol Toxicol       Date:  1990       Impact factor: 13.820

Review 4.  Discontinuous transcription and antigenic variation in trypanosomes.

Authors:  P Borst
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

5.  Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro.

Authors:  N K Borowy; J M Sternberg; D Schreiber; C Nonnengasser; P Overath
Journal:  Parasite Immunol       Date:  1990-05       Impact factor: 2.280

6.  Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.

Authors:  K W Schleifer; J M Mansfield
Journal:  J Immunol       Date:  1993-11-15       Impact factor: 5.422

7.  Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection.

Authors:  J Sternberg; F McGuigan
Journal:  Eur J Immunol       Date:  1992-10       Impact factor: 5.532

8.  Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei.

Authors:  P Vincendeau; S Daulouède; B Veyret; M L Darde; B Bouteille; J L Lemesre
Journal:  Exp Parasitol       Date:  1992-11       Impact factor: 2.011

9.  Dual role of macrophages in the suppression of interleukin 2 production and interleukin 2 receptor expression in trypanosome-infected mice.

Authors:  M Sileghem; A Darji; R Hamers; M Van de Winkel; P De Baetselier
Journal:  Eur J Immunol       Date:  1989-05       Impact factor: 5.532

10.  Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense.

Authors:  T Baltz; D Baltz; C Giroud; J Crockett
Journal:  EMBO J       Date:  1985-05       Impact factor: 11.598
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  16 in total

Review 1.  Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

Authors:  F C Fang
Journal:  J Clin Invest       Date:  1997-06-15       Impact factor: 14.808

2.  Nitric oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression.

Authors:  K Taylor; V Lutje; B Mertens
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

3.  The impact of l-arginine supplementation on the enteral phase of experimental Trichinella spiralis infection in treated and untreated mice.

Authors:  Hanaa O Fadl; Noha M Amin; Hanaa Wanas; Shimaa Saad El-Din; Heba A Ibrahim; Basma Emad Aboulhoda; Nardeen Zakka Bocktor
Journal:  J Parasit Dis       Date:  2020-07-25

4.  L-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis.

Authors:  A P Gobert; S Daulouede; M Lepoivre; J L Boucher; B Bouteille; A Buguet; R Cespuglio; B Veyret; P Vincendeau
Journal:  Infect Immun       Date:  2000-08       Impact factor: 3.441

5.  Nitric oxide produced in the lungs of mice immunized with the radiation-attenuated schistosome vaccine is not the major agent causing challenge parasite elimination.

Authors:  P S Coulson; L E Smythies; C Betts; N A Mabbott; J M Sternberg; X G Wei; F Y Liew; R A Wilson
Journal:  Immunology       Date:  1998-01       Impact factor: 7.397

6.  Bone marrow nitric oxide production and development of anemia in Trypanosoma brucei-infected mice.

Authors:  N Mabbott; J Sternberg
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

7.  Effect of nitric oxide releasing drugs on the intensity of infection during experimental trichinellosis in mice.

Authors:  Elzbieta Wandurska-Nowak; Edward Hadaś; Monika Derda; Waldemar Wojt
Journal:  Parasitol Res       Date:  2003-03-12       Impact factor: 2.289

8.  Different susceptibilities of yeasts and conidia of Penicillium marneffei to nitric oxide (NO)-mediated fungicidal activity of murine macrophages.

Authors:  N Kudeken; K Kawakami; A Saito
Journal:  Clin Exp Immunol       Date:  1998-05       Impact factor: 4.330

9.  T-Cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase.

Authors:  A E Millar; J Sternberg; C McSharry; X Q Wei; F Y Liew; C M Turner
Journal:  Infect Immun       Date:  1999-07       Impact factor: 3.441

10.  Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection.

Authors:  Omar A Alfituri; Enock M Mararo; Pieter C Steketee; Liam J Morrison; Neil A Mabbott
Journal:  Sci Rep       Date:  2021-05-10       Impact factor: 4.379
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