Literature DB >> 8168980

Differential expression of the cytotoxic and hemolytic activities of the ApxIIA toxin from Actinobacillus pleuropneumoniae.

A H Tu1, C Hausler, R Young, D K Struck.   

Abstract

The ApxIIA protein secreted from Actinobacillus pleuropneumoniae is both hemolytic and cytotoxic. However, when the cloned apxII operon is expressed in Escherichia coli, two forms of the ApxIIA protein can be recovered. Toxin which remains intracellular has hemolytic and cytotoxic activities, while toxin that is secreted is cytotoxic with little or no hemolytic activity. This indicates that the cytotoxicity of ApxIIA is independent of its hemolytic activity.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8168980      PMCID： PMC186478          DOI： 10.1128/iai.62.5.2119-2121.1994

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  14 in total

Review 1.  Pore-forming cytolysins of gram-negative bacteria.

Authors:  R A Welch
Journal:  Mol Microbiol       Date:  1991-03       Impact factor: 3.501

2.  Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation.

Authors:  J P Issartel; V Koronakis; C Hughes
Journal:  Nature       Date:  1991-06-27       Impact factor: 49.962

3.  Separable domains define target cell specificities of an RTX hemolysin from Actinobacillus pleuropneumoniae.

Authors:  D R McWhinney; Y F Chang; R Young; D K Struck
Journal:  J Bacteriol       Date:  1992-01       Impact factor: 3.490

4.  Escherichia coli HlyT protein, a transcriptional activator of haemolysin synthesis and secretion, is encoded by the rfaH (sfrB) locus required for expression of sex factor and lipopolysaccharide genes.

Authors:  M J Bailey; V Koronakis; T Schmoll; C Hughes
Journal:  Mol Microbiol       Date:  1992-04       Impact factor: 3.501

5.  TolC, an Escherichia coli outer membrane protein required for hemolysin secretion.

Authors:  C Wandersman; P Delepelaire
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

6.  Loss of activity in the secreted form of Escherichia coli haemolysin caused by an rfaP lesion in core lipopolysaccharide assembly.

Authors:  P L Stanley; P Diaz; M J Bailey; D Gygi; A Juarez; C Hughes
Journal:  Mol Microbiol       Date:  1993-11       Impact factor: 3.501

7.  In vitro activation of Escherichia coli prohaemolysin to the mature membrane-targeted toxin requires HlyC and a low molecular-weight cytosolic polypeptide.

Authors:  K R Hardie; J P Issartel; E Koronakis; C Hughes; V Koronakis
Journal:  Mol Microbiol       Date:  1991-07       Impact factor: 3.501

8.  Nucleotide sequence of the hemolysin I gene from Actinobacillus pleuropneumoniae.

Authors:  J Frey; R Meier; D Gygi; J Nicolet
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

9.  Identification of hemolytic and cytotoxic proteins of Actinobacillus pleuropneumoniae by use of monoclonal antibodies.

Authors:  E M Kamp; J K Popma; J Anakotta; M A Smits
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

10.  Cloning and characterization of a hemolysin gene from Actinobacillus (Haemophilus) pleuropneumoniae.

Authors:  Y F Chang; R Young; D K Struck
Journal:  DNA       Date:  1989-11
View more
  2 in total

Review 1.  Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.

Authors:  P Stanley; V Koronakis; C Hughes
Journal:  Microbiol Mol Biol Rev       Date:  1998-06       Impact factor: 11.056

2.  Polymorphism analysis of the apxIA gene of Actinobacillus pleuropneumoniae serovar 5 isolated in swine herds from Brazil.

Authors:  Lucas Fernando Dos Santos; Richard Costa Polveiro; Thalita Scatamburlo Moreira; Pedro Marcus Pereira Vidigal; Yung-Fu Chang; Maria Aparecida Scatamburlo Moreira
Journal:  PLoS One       Date:  2018-12-18       Impact factor: 3.240
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.