Pattern of development of the callosal transfer of visual information to cortical areas 17 and 18 in the cat.

The aim of this study was to investigate the development of visual callosal transfer in the normally reared cat. Two- to nine-week-old kittens and adults (used as controls) underwent section of the optic chiasm. Three days later, the animals were placed under anesthesia and paralysed; unit activities were recorded from visual cortical areas 17 and 18 and from the white matter in one hemisphere. The units were tested for their responses to visual stimulation of each eye successively. Out of 1036 recorded neurons, 185 could be activated through the eye contralateral to the explored cortex via callosal transfer. Most of them could also be driven through the ipsilateral eye via the 'direct' geniculo-cortical pathway. For animals aged > or = 2 weeks, virtually all of these units were located at the 17/18 border zone, with a majority in the supragranular layers. When activated through the corpus callosum, they displayed receptive fields located either on the central vertical meridian of the visual field or in the hemifield ipsilateral to the explored cortex. Such extension into the ipsilateral hemifield as well as receptive field disparities of binocular units decreased with age, while spontaneous activity, strength of response, orientation selectivity and ability to respond to slits moving at middle-range velocity increased. The main conclusion is that the transient callosal projections described by anatomists, which are present until 3 months of age, do not achieve supraliminar synaptic contacts with parts of areas 17 and 18 other than the 17/18 border zone, at least from 12 days after birth. However the visual callosal transfer in young animals displays some characteristics which disappear with age.