Fibrinogen: an important risk factor for atherothrombotic diseases.

Epidemiological follow-up studies have suggested that fibrinogen is a major, primary cardiovascular risk factor. Cross-sectional results also show associations between fibrinogen and cardiovascular risk factors or diseases. Clinical cohort studies demonstrate that fibrinogen might also be a secondary risk factor. The determinants of the plasma level of fibrinogen in health and disease are known only incompletely. Our understanding of the mechanisms involved in the atherogenic actions of fibrinogen is similarly fragmentary. These might include blood coagulation, blood rheology, platelet aggregation, direct effects on the vascular wall, and the acute phase response. Thus, many questions are yet to be answered. Nevertheless, the data available at present strongly suggest that fibrinogen represents a major, independent cardiovascular risk factor. Fibrinogen should be considered for screening programmes aimed at identifying individuals at risk.