Literature DB >> 8166740

Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells.

Y Ishizaka1, Y Ishizaka1, M Tanaka, K Kitamura, K Kangawa, N Minamino, H Matsuo, T Eto.   

Abstract

A newly identified human peptide, adrenomedullin (AM) increased cAMP levels with dose and time dependencies in a manner similar to that of human calcitonin gene-related peptide (CGRP) in rat vascular smooth muscle cells (VSMC). The EC50 value of human AM is 2 x 10(-8) M which is slightly higher than that of CGRP (8.5 x 10(-9) M). In a receptor binding assay for AM in rat VSMC, the binding of [125I] AM was competitively inhibited by human AM, but not by human CGRP. Thus, AM is thought to increase intracellular cAMP in rat VSMC via its specific receptor to evoke vasodilation.

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Year:  1994        PMID： 8166740     DOI： 10.1006/bbrc.1994.1496

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  27 in total

1.  Role of adrenomedullin in Lyme disease.

Authors:  Meghan L Marre; Courtney T Darcy; Janeth Yinh; Shizuo Akira; Satoshi Uematsu; Allen C Steere; Linden T Hu
Journal:  Infect Immun       Date:  2010-10-04       Impact factor: 3.441

2.  Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity.

Authors:  H A Coppock; A A Owji; C Austin; P D Upton; M L Jackson; J V Gardiner; M A Ghatei; S R Bloom; D M Smith
Journal:  Biochem J       Date:  1999-02-15       Impact factor: 3.857

Review 3.  CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?

Authors:  C S Walker; D L Hay
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

Review 4.  Novel neurohumoral factors in congestive heart failure: adrenomedullin.

Authors:  J G Lainchbury
Journal:  Curr Cardiol Rep       Date:  2001-05       Impact factor: 2.931

5.  Adrenomedullin suppresses fMLP-induced upregulation of CD11b of human neutrophils.

Authors:  Y Saito; C Nakagawa; H Uchida; F Sasaki; H Sakakibara
Journal:  Inflammation       Date:  2001-06       Impact factor: 4.092

Review 6.  Adrenomedullin. Implications for hypertension research.

Authors:  K Kitamura; K Kangawa; H Matsuo; T Eto
Journal:  Drugs       Date:  1995-04       Impact factor: 9.546

7.  A rat skeletal muscle cell line (L6) expresses specific adrenomedullin binding sites but activates adenylate cyclase via calcitonin gene-related peptide receptors.

Authors:  H A Coppock; A A Owji; S R Bloom; D M Smith
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

8.  Analysis of responses to human synthetic adrenomedullin and calcitonin gene-related peptides in the hindlimb vascular bed of the cat.

Authors:  H C Champion; D L Akers; J A Santiago; D G Lambert; D B McNamara; P J Kadowitz
Journal:  Mol Cell Biochem       Date:  1997-11       Impact factor: 3.396

9.  Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1.

Authors:  Katherine E Wiley; Anthony P Davenport
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

10.  Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions.

Authors:  Wenjing Xu; Erika S Wittchen; Samantha L Hoopes; Lucia Stefanini; Keith Burridge; Kathleen M Caron
Journal:  Arterioscler Thromb Vasc Biol       Date:  2018-10       Impact factor: 8.311
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