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Literature DB >> 8166639

Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells.

J L Mitchell¹, G G Judd, A Bareyal-Leyser, S Y Ling.

Abstract

Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxylase cell lines, we demonstrate that this newly discovered action of antizyme is distinct from its role in modulating polyamine biosynthesis.

Entities: Chemical Gene Species

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Year: 1994 PMID： 8166639 PMCID： PMC1138014 DOI： 10.1042/bj2990019

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

29 in total

Review 1. Polyamine membrane transport regulation.

Authors: N A Khan; V Quemener; J P Moulinoux
Journal: Cell Biol Int Rep Date: 1991-01

2. Feedback repression of polyamine uptake into mammalian cells requires active protein synthesis.

Authors: J L Mitchell; R R Diveley; A Bareyal-Leyser
Journal: Biochem Biophys Res Commun Date: 1992-07-15 Impact factor: 3.575

3. Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme.

Authors: X Li; P Coffino
Journal: Mol Cell Biol Date: 1992-08 Impact factor: 4.272

4. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination.

Authors: Y Murakami; S Matsufuji; T Kameji; S Hayashi; K Igarashi; T Tamura; K Tanaka; A Ichihara
Journal: Nature Date: 1992-12-10 Impact factor: 49.962

5. Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein.

Authors: X Li; P Coffino
Journal: Mol Cell Biol Date: 1993-04 Impact factor: 4.272

6. Involvement of the 20S proteasome in the degradation of ornithine decarboxylase.

Authors: Z Bercovich; C Kahana
Journal: Eur J Biochem Date: 1993-04-01

7. Single amino-acid replacement is responsible for the stabilization of ornithine decarboxylase in HMOA cells.

Authors: Y Miyazaki; S Matsufuji; Y Murakami; S Hayashi
Journal: Eur J Biochem Date: 1993-06-15

8. Stable ornithine decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine.

Authors: J L Mitchell; J A Hoff; A Bareyal-Leyser
Journal: Arch Biochem Biophys Date: 1991-10 Impact factor: 4.013

Review 9. A new perspective on ornithine decarboxylase regulation: prevention of polyamine toxicity is the overriding theme.

Authors: D R Morris
Journal: J Cell Biochem Date: 1991-06 Impact factor: 4.429

10. Abnormal accumulation and toxicity of polyamines in a difluoromethylornithine-resistant HTC cell variant.

Authors: J L Mitchell; R R Diveley; A Bareyal-Leyser; J L Mitchell
Journal: Biochim Biophys Acta Date: 1992-08-12

65 in total

1. Antizyme affects cell proliferation and viability solely through regulating cellular polyamines.

Authors: Zippi Bercovich; Zohar Snapir; Alona Keren-Paz; Chaim Kahana
Journal: J Biol Chem Date: 2011-08-10 Impact factor: 5.157

Review 2. Recent advances in the molecular biology of metazoan polyamine transport.

Authors: R Poulin; R A Casero; D Soulet
Journal: Amino Acids Date: 2011-08-04 Impact factor: 3.520

3. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.

Authors: Alison V Fraser; Andrew C Goodwin; Amy Hacker-Prietz; Elizabeth Sugar; Patrick M Woster; Robert A Casero
Journal: Amino Acids Date: 2011-08-04 Impact factor: 3.520

10. Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion.

Authors: Kristiina Kanerva; Jani Lappalainen; Laura T Mäkitie; Susanna Virolainen; Petri T Kovanen; Leif C Andersson
Journal: PLoS One Date: 2009-08-31 Impact factor: 3.240