Literature DB >> 8164223

3 cases of anti-Scl-70 (topoisomerase I) antibody associated with central nervous system lupus without renal disorder.

M Mukai1, A Sagawa, T Atsumi, S Jodo, Y Amasaki, T Nakabayashi, I Watanabe, A Fujisaku, S Nakagawa.   

Abstract

We describe 3 cases of systemic lupus erythematosus (SLE) associated with anti-Scl-70 antibody. Common symptoms were central nervous system disorder, discoid rash, lymphadenopathy, and no renal disorder. Two of 3 cases showed some symptoms of scleroderma but could not be diagnosed as such. Although further followup is required to determine if scleroderma develops, these unique symptoms might be a subtype of SLE or a lupus-like syndrome characterized by symptoms and anti-Scl-70 antibody.

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Year:  1993        PMID： 8164223

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  3 in total

1.  Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis.

Authors:  Mohamed A Hamidou; Marie A Audrain; Agathe Masseau; Christian Agard; Anne Moreau
Journal:  Clin Rheumatol       Date:  2006-03-07       Impact factor: 2.980

2.  Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.

Authors:  Minoru Satoh; Malgorzata E Krzyszczak; Yi Li; Angela Ceribelli; Steven J Ross; Edward K L Chan; Mark S Segal; Michael R Bubb; Eric S Sobel; Westley H Reeves
Journal:  Arthritis Res Ther       Date:  2011-05-10       Impact factor: 5.156

3.  Detection of anti-topoisomerase I antibodies using a full length human topoisomerase I recombinant protein purified from a baculovirus expression system.

Authors:  J Whyte; W C Earnshaw; J J Champoux; L H Parker; L Stewart; N D Hall; N J McHugh
Journal:  Clin Exp Immunol       Date:  1995-05       Impact factor: 4.330
  3 in total

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