Literature DB >> 8163168

Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.

E S Kim1, M J Bibb, M J Butler, D A Hopwood, D H Sherman.   

Abstract

The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric beta-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.

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Year:  1994        PMID： 8163168     DOI： 10.1016/0378-1119(94)90144-9

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

1.  Acyl carrier protein structural classification and normal mode analysis.

Authors:  David C Cantu; Michael J Forrester; Katherine Charov; Peter J Reilly
Journal:  Protein Sci       Date:  2012-03-29       Impact factor: 6.725

2.  An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.

Authors:  Bryan D Ellis; Jacob C Milligan; Alexander R White; Vy Duong; Pilar X Altman; Lina Y Mohammed; Matthew P Crump; John Crosby; Ray Luo; Christopher D Vanderwal; Shiou-Chuan Tsai
Journal:  J Am Chem Soc       Date:  2018-04-10       Impact factor: 15.419

3.  Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus.

Authors:  Irene Saugar; Brian Molloy; Eloisa Sanz; María Blanca Sánchez; María Fernández-Lobato; Antonio Jiménez
Journal:  J Antibiot (Tokyo)       Date:  2016-10-12       Impact factor: 2.649

Review 4.  Oxytetracycline biosynthesis.

Authors:  Lauren B Pickens; Yi Tang
Journal:  J Biol Chem       Date:  2010-06-03       Impact factor: 5.157

5.  Developmental regulation of transcription of whiE, a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3 (2)

Authors:  G H Kelemen; P Brian; K Flärdh; L Chamberlin; K F Chater; M J Buttner
Journal:  J Bacteriol       Date:  1998-05       Impact factor: 3.490

6.  Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Authors:  Wenjun Zhang; Brian D Ames; Shiou-Chuan Tsai; Yi Tang
Journal:  Appl Environ Microbiol       Date:  2006-04       Impact factor: 4.792

7.  Phosphate control of oxytetracycline production by Streptomyces rimosus is at the level of transcription from promoters overlapped by tandem repeats similar to those of the DNA-binding sites of the OmpR family.

Authors:  K J McDowall; A Thamchaipenet; I S Hunter
Journal:  J Bacteriol       Date:  1999-05       Impact factor: 3.490

8.  A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms.

Authors:  K T Seow; G Meurer; M Gerlitz; E Wendt-Pienkowski; C R Hutchinson; J Davies
Journal:  J Bacteriol       Date:  1997-12       Impact factor: 3.490

9.  A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.

Authors:  K Ylihonko; J Tuikkanen; S Jussila; L Cong; P Mäntsälä
Journal:  Mol Gen Genet       Date:  1996-05-23

10.  Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase.

Authors:  Jason M Crawford; Blair C R Dancy; Eric A Hill; Daniel W Udwary; Craig A Townsend
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-27       Impact factor: 11.205
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