| Literature DB >> 8162068 |
P H Sorensen1, S L Lessnick, D Lopez-Terrada, X F Liu, T J Triche, C T Denny.
Abstract
The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the ETS family member, FLI-1. This results in the expression of a chimaeric protein containing the amino-terminal portion of EWS fused to the ETS DNA-binding domain of FLI-1. We have identified a second Ewing's sarcoma translocation, t(21;22)(q22;q12), that fuses EWS to a different ETS family member, the ERG gene located on band 21q22. Identical EWS nucleotide sequences found in the EWS/FLI-1 fusion transcripts are fused to portions of ERG encoding an ETS DNA-binding domain resulting in expression of a hybrid EWS/ERG protein. These findings suggest that fusion of EWS to different members of the ETS family of transcription factor genes may result in the expression of similar disease phenotypes.Entities:
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Year: 1994 PMID： 8162068 DOI： 10.1038/ng0294-146
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330