F Cosentino1, Z S Katusić. 1. Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905.
Abstract
BACKGROUND: Endothelin-1 is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. Its long-lasting vasoconstrictor and hypertensive action has been well documented in several species, including humans. SUMMARY OF REVIEW: It is generally accepted that endothelin-1 may contribute to the pathogenesis of a number of cardiovascular diseases. In the cerebral vasculature, endothelin-1 has been proposed as a key mediator of cerebral vasospasm following subarachnoid hemorrhage. Availability of endothelin-1 antagonist provided a pharmacologic tool to test the role of endothelin in the development of vasospasm. CONCLUSIONS: This brief review is focused on the controversial results reported by different groups concerning the possible role of endothelin-1 in narrowing of cerebral arteries exposed to autologous blood.
BACKGROUND:Endothelin-1 is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. Its long-lasting vasoconstrictor and hypertensive action has been well documented in several species, including humans. SUMMARY OF REVIEW: It is generally accepted that endothelin-1 may contribute to the pathogenesis of a number of cardiovascular diseases. In the cerebral vasculature, endothelin-1 has been proposed as a key mediator of cerebral vasospasm following subarachnoid hemorrhage. Availability of endothelin-1 antagonist provided a pharmacologic tool to test the role of endothelin in the development of vasospasm. CONCLUSIONS: This brief review is focused on the controversial results reported by different groups concerning the possible role of endothelin-1 in narrowing of cerebral arteries exposed to autologous blood.
Authors: Patrick W Alford; Borna E Dabiri; Josue A Goss; Matthew A Hemphill; Mark D Brigham; Kevin Kit Parker Journal: Proc Natl Acad Sci U S A Date: 2011-07-15 Impact factor: 11.205