Literature DB >> 815976

The effect of homogenisation on the level of scrapie activity detected in cells from spleens of scrapie affected mice.

M C Clarke, D A Haig.   

Abstract

Suspensions of cells from the spleens of mice inoculated with scrapie agent were titrated for scrapie activity at two stages, before and after disruption to release activity. Similarity between the titres obtained from the two types of suspension provided evidence to support the suggestion that there is one unit of activity per affected cell and that multiplication of scrapie agent is associated with cell replication.

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Year:  1976        PMID： 815976

Source DB:  PubMed          Journal:  Res Vet Sci        ISSN： 0034-5288            Impact factor:   2.534


  3 in total

1.  Enhanced M-CSF/CSF1R Signaling Closely Associates with PrPSc Accumulation in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.

Authors:  Ying Xia; Cao Chen; Jia Chen; Chao Hu; Wei Yang; Lin Wang; Lian Liu; Li-Ping Gao; Yue-Zhang Wu; Dong-Dong Chen; Qi Shi; Zhi-Bao Chen; Xiao-Ping Dong
Journal:  Mol Neurobiol       Date:  2022-08-15       Impact factor: 5.682

2.  Attempts to establish the scrapie agent in cell lines.

Authors:  C J Elleman
Journal:  Vet Res Commun       Date:  1984-11       Impact factor: 2.459

3.  Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.

Authors:  Candace K Mathiason; Sheila A Hays; Jenny Powers; Jeanette Hayes-Klug; Julia Langenberg; Sallie J Dahmes; David A Osborn; Karl V Miller; Robert J Warren; Gary L Mason; Edward A Hoover
Journal:  PLoS One       Date:  2009-06-16       Impact factor: 3.240
  3 in total

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