Literature DB >> 8159754

Kinetics of an RNA conformational switch.

K A LeCuyer1, D M Crothers.   

Abstract

The spliced leader RNA from Leptomonas collosoma has two competing secondary structures of nearly equal free energy. Short, complementary oligonucleotides can drive the structure from one form of the other. We report stopped-flow rapid-mixing and temperature-jump measurements of the kinetics of the structural switch. At high concentrations of oligonucleotide, the rate of binding becomes limited by the rate of the structural switch, which occurs on a time scale of a fraction of a second. The low activation energy observed for the process implies a branch migration type of mechanism in which portions of the two competing helices transiently coexist.

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Year:  1994        PMID： 8159754      PMCID： PMC43579          DOI： 10.1073/pnas.91.8.3373

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

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Journal:  Science       Date:  1992-08-14       Impact factor: 47.728

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5.  Conformational changes of transfer ribonucleic acid. Relaxation kinetics of the early melting transition of methionine transfer ribonucleic acid (Escherichia coli).

Authors:  P E Cole; D M Crothers
Journal:  Biochemistry       Date:  1972-11-07       Impact factor: 3.162

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Journal:  J Mol Biol       Date:  1971-12-14       Impact factor: 5.469

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