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Literature DB >> 8159708

The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development.

J C Kraft¹, T Schuh, M Juchau, D Kimelman.

Abstract

Endogenous retinoids are potential regulators of vertebrate embryogenesis that have been implicated in early anterior-posterior patterning and limb-bud development. We have characterized the temporal and spatial distribution of 9-cis-retinoic acid in the Xenopus embryo and compared it to two other retinoids, all-trans-retinoic acid and all-trans-retinoyl-beta-glucuronide. 9-cis-Retinoic acid is first detected after the midblastula transition and by the end of gastrulation is localized primarily within the anterior and posterior dorsal regions of the embryo. Since 9-cis-retinoic acid is a 6-fold more potent dysmorphogen than trans-retinoic acid, we suggest that it is involved in the early specification of the Xenopus anterior-posterior axis.

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Year: 1994 PMID： 8159708 PMCID： PMC43516 DOI： 10.1073/pnas.91.8.3067

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

34 in total

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Journal: Cell Date: 1991-10-04 Impact factor: 41.582

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Journal: Genes Dev Date: 1991-02 Impact factor: 11.361

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Journal: Nature Date: 1992-09-17 Impact factor: 49.962

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Journal: Proc Natl Acad Sci U S A Date: 1992-11-01 Impact factor: 11.205

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Journal: EMBO J Date: 1991-10 Impact factor: 11.598

15 in total

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Authors: Ayala Luria; J David Furlow
Journal: Proc Natl Acad Sci U S A Date: 2004-06-03 Impact factor: 11.205

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4. 9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein.

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5. Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis.

Authors: M Puzianowska-Kuznicka; S Damjanovski; Y B Shi
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Journal: Proc Natl Acad Sci U S A Date: 1996-03-05 Impact factor: 11.205

7. Divergent teratogenicity of agonists of retinoid X receptors in embryos of zebrafish (Danio rerio).

Authors: Huahong Shi; Pan Zhu; Zhi Sun; Bo Yang; Liang Zheng
Journal: Ecotoxicology Date: 2012-04-10 Impact factor: 2.823

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10. Defining progressive stages in the commitment process leading to embryonic lens formation.

Authors: Hong Jin; Marilyn Fisher; Robert M Grainger
Journal: Genesis Date: 2012-06-19 Impact factor: 2.487