Literature DB >> 8158162

Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.

R Mierzwa1, A King, M A Conover, S Tozzi, M S Puar, M Patel, S J Coval, S A Pomponi.   

Abstract

The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.

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Year:  1994        PMID： 8158162     DOI： 10.1021/np50103a029

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

Review 1.  The marine bromotyrosine derivatives.

Authors:  Jiangnan Peng; Jing Li; Mark T Hamann
Journal:  Alkaloids Chem Biol       Date:  2005

2.  Total Synthesis (+)-7-Bromotrypargine and Unnatural Analogs: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance.

Authors:  John T Brogan; Sydney L Stoops; Brenda C Crews; Lawrence J Marnett; Craig W Lindsley
Journal:  ACS Chem Neurosci       Date:  2011-11-16       Impact factor: 4.418

3.  A novel natural phenyl alkene with cytotoxic activity.

Authors:  In Hyun Hwang; Joonseok Oh; Anna Kochanowska-Karamyan; Robert J Doerksen; MinKyun Na; Mark T Hamann
Journal:  Tetrahedron Lett       Date:  2013-05-18       Impact factor: 2.415

4.  Total synthesis and biological evaluation of phidianidines A and B uncovers unique pharmacological profiles at CNS targets.

Authors:  John T Brogan; Sydney L Stoops; Craig W Lindsley
Journal:  ACS Chem Neurosci       Date:  2012-06-27       Impact factor: 4.418

5.  Eosinophils generate brominating oxidants in allergen-induced asthma.

Authors:  W Wu; M K Samoszuk; S A Comhair; M J Thomassen; C F Farver; R A Dweik; M S Kavuru; S C Erzurum; S L Hazen
Journal:  J Clin Invest       Date:  2000-05       Impact factor: 14.808

Review 6.  Recent progress in neuroactive marine natural products.

Authors:  Ryuichi Sakai; Geoffrey T Swanson
Journal:  Nat Prod Rep       Date:  2014-01-17       Impact factor: 13.423

7.  A Model Study toward the Concise Synthesis of Bromotyrosine Derived Spiroisoxazoline Natural Products and Analogous Core Structures.

Authors:  Prasanta Das; Edward J Valente; Ashton T Hamme
Journal:  European J Org Chem       Date:  2014-05-01

8.  Application of Networking Approaches to Assess the Chemical Diversity, Biogeography, and Pharmaceutical Potential of Verongiida Natural Products.

Authors:  James Lever; Robert Brkljača; Colin Rix; Sylvia Urban
Journal:  Mar Drugs       Date:  2021-10-18       Impact factor: 5.118

9.  Bromotyrosine-derived alkaloids from the Caribbean sponge Aplysina lacunosa.

Authors:  Qun Göthel; Thanchanok Sirirak; Matthias Köck
Journal:  Beilstein J Org Chem       Date:  2015-11-26       Impact factor: 2.883

10.  Bioactive Bromotyrosine Derivatives from the Pacific Marine Sponge Suberea clavata (Pulitzer-Finali, 1982).

Authors:  Céline Moriou; Damien Lacroix; Sylvain Petek; Amr El-Demerdash; Rozenn Trepos; Tinihauarii Mareva Leu; Cristina Florean; Marc Diederich; Claire Hellio; Cécile Debitus; Ali Al-Mourabit
Journal:  Mar Drugs       Date:  2021-03-06       Impact factor: 5.118
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