Literature DB >> 8158151

Neuromelanin of the human substantia nigra: a mixed-type melanin.

G Odh1, R Carstam, J Paulson, A Wittbjer, E Rosengren, H Rorsman.   

Abstract

Model melanins, synthesized with different cysteinyldopamine/dopamine ratios in the incubates, were oxidized with KMnO4 and the resulting compounds were analyzed by HPLC. The ratios between a phaeomelanin-derived compound, thiazole-4,5-dicarboxylic acid (TDCA), and a compound derived from eumelanin, pyrrole-2,3,5-tricarboxylic acid (PTCA), reflected the composition of the model melanins. The neuromelanin of the human substantia nigra was isolated, and the pigment, as well as intact brain tissue from human substantia nigra was oxidized with KMnO4 and the TDCA/PTCA ratios were determined. Analysis of the isolated neuromelanin showed it to contain 2.3% sulfur and 8.1% nitrogen. The sulfur content indicates the pigment is a mixed-type melanin, and the TDCA/PTCA ratio indicates that it consists of units derived from benzothiazines and from indoles in about equal amounts.

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Year:  1994        PMID： 8158151     DOI： 10.1046/j.1471-4159.1994.62052030.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  12 in total

Review 1.  The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease.

Authors:  K A Jellinger
Journal:  Drugs Aging       Date:  1999-02       Impact factor: 3.923

2.  Structural investigations of neuromelanin by pyrolysis-gas chromatography/mass spectrometry.

Authors:  A Dzierzega-Lecznar; S Kurkiewicz; K Stepien; E Chodurek; P Riederer; M Gerlach
Journal:  J Neural Transm (Vienna)       Date:  2006-05-12       Impact factor: 3.575

3.  The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.

Authors:  William D Bush; Jacob Garguilo; Fabio A Zucca; Alberto Albertini; Luigi Zecca; Glenn S Edwards; Robert J Nemanich; John D Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-25       Impact factor: 11.205

Review 4.  Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.

Authors:  L Zecca; D Tampellini; M Gerlach; P Riederer; R G Fariello; D Sulzer
Journal:  Mol Pathol       Date:  2001-12

5.  Model neuromelanins as antioxidative agents during lipid peroxidation.

Authors:  T Wilczok; K Stepien; A Dzierzega-Lecznar; A Zajdel; A Wilczok
Journal:  Neurotox Res       Date:  1999-12       Impact factor: 3.911

6.  Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification.

Authors:  F Solano; V J Hearing; J C García-Borrón
Journal:  Neurotox Res       Date:  2000-02       Impact factor: 3.911

7.  The neurotoxicity of glutamate, dopamine, iron and reactive oxygen species: functional interrelationships in health and disease: a review-discussion.

Authors:  J Smythies
Journal:  Neurotox Res       Date:  1999-09       Impact factor: 3.911

8.  Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase.

Authors:  Arthur J L Cooper; John T Pinto; Boris F Krasnikov; Zoya V Niatsetskaya; Qian Han; Jianyong Li; David Vauzour; Jeremy P E Spencer
Journal:  Arch Biochem Biophys       Date:  2008-02-29       Impact factor: 4.013

9.  GC/MS analysis of thermally degraded neuromelanin from the human substantia nigra.

Authors:  Anna Dzierzega-Lecznar; Slawomir Kurkiewicz; Krystyna Stepien; Ewa Chodurek; Tadeusz Wilczok; Thomas Arzberger; Peter Riederer; Manfred Gerlach
Journal:  J Am Soc Mass Spectrom       Date:  2004-06       Impact factor: 3.109

10.  An XAS study of the sulfur environment in human neuromelanin and its synthetic analogs.

Authors:  Pier Raimondo Crippa; Melvin Eisner; Silvia Morante; Francesco Stellato; Flavio C Vicentin; Luigi Zecca
Journal:  Eur Biophys J       Date:  2009-05-27       Impact factor: 1.733
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