Literature DB >> 8157764

Expression of parathyroid hormone related peptide in human pituitary tumours.

M Ito1, H Enomoto, T Usa, M C Villadolid, A Ohtsuru, H Namba, I Sekine, S Yamashita.   

Abstract

The presence of parathyroid hormone related peptide (PTHrP) was studied in 20 patients with pituitary adenomas and one patient with pituitary adenocarcinoma. PTHrP expression was shown in almost all of the pituitary adenomas (95%) and in 100% (n = 7) growth hormone producing pituitary adenomas. A metastatic lesion from a pituitary growth hormone producing adenocarcinoma revealed strongly expressed PTHrP. It was weakly detected in normal pituitary cells in all of the specimens (n = 10). There was no significant correlation, however, between PTHrP expression and the clinical or pathological features of growth hormone producing tumours. Apart from an important role in the physiological function of the pituitary gland, PTHrP may be closely related to somatotroph tumorigenicity.

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Year:  1993        PMID： 8157764      PMCID： PMC501406          DOI： 10.1136/jcp.46.7.682

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  20 in total

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Authors:  A H Tashjian
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

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Authors:  G A Schnell; T T Schubert
Journal:  Am J Gastroenterol       Date:  1989-02       Impact factor: 10.864

4.  Rapid diagnosis of Campylobacter pyloridis infection.

Authors:  S S Das; L A Bain; Q N Karim; L G Coelho; J H Baron
Journal:  J Clin Pathol       Date:  1987-06       Impact factor: 3.411

5.  Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas.

Authors:  K Ikeda; E C Weir; M Mangin; P S Dannies; B Kinder; L J Deftos; E M Brown; A E Broadus
Journal:  Mol Endocrinol       Date:  1988-12

6.  Four hour rapid urease test (RUT) for detecting Campylobacter pylori: is it reliable enough to start treatment?

Authors:  D Vaira; J Holton; S Cairns; M Falzon; P Salmon
Journal:  J Clin Pathol       Date:  1988-03       Impact factor: 3.411

7.  Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.

Authors:  G J Strewler; P H Stern; J W Jacobs; J Eveloff; R F Klein; S C Leung; M Rosenblatt; R A Nissenson
Journal:  J Clin Invest       Date:  1987-12       Impact factor: 14.808

8.  Rapid urease test in the management of Campylobacter pyloridis-associated gastritis.

Authors:  B J Marshall; J R Warren; G J Francis; S R Langton; C S Goodwin; E D Blincow
Journal:  Am J Gastroenterol       Date:  1987-03       Impact factor: 10.864

9.  Parathyroid hormone-related protein purified from a human lung cancer cell line.

Authors:  J M Moseley; M Kubota; H Diefenbach-Jagger; R E Wettenhall; B E Kemp; L J Suva; C P Rodda; P R Ebeling; P J Hudson; J D Zajac
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

10.  Campylobacter pyloridis gastritis I: Detection of urease as a marker of bacterial colonization and gastritis.

Authors:  S L Hazell; T J Borody; A Gal; A Lee
Journal:  Am J Gastroenterol       Date:  1987-04       Impact factor: 10.864
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  4 in total

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Authors:  L Manetti; L Grasso; C Vignali; P Petruzzi; I Lupi; M Genovesi; L L Morselli; F Cetani; G Acerbi; E Martino
Journal:  J Endocrinol Invest       Date:  2005-10       Impact factor: 4.256

2.  Distribution of the parathyroid hormone-related peptide and its receptor in the saccus vasculosus and choroid plexus in the red stingray (Dasyatis akajei: Elasmobranch).

Authors:  K Akino; A Ohtsuru; M Nakashima; M Ito; Y Ting-Ting; V Braiden; T Kawawaki; J Baba; S Yamashita; N Iwahori
Journal:  Cell Mol Neurobiol       Date:  1998-06       Impact factor: 5.046

3.  Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression.

Authors:  M Ito; M Nakashima; G K Alipov; S Matsuzaki; A Ohtsuru; H Yano; S Yamashita; I Sekine
Journal:  J Gastroenterol       Date:  1997-06       Impact factor: 7.527

4.  The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells.

Authors:  Ramanaiah Mamillapalli; John Wysolmerski
Journal:  J Endocrinol       Date:  2009-12-23       Impact factor: 4.286
  4 in total

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