Literature DB >> 8157073

Glutamatergic regulation of cannabinoid receptor gene expression in the caudate-putamen.

P Mailleux1, J J Vanderhaeghen.   

Abstract

Glutamatergic regulation of delta-9-tetrahydrocannabinol (THC) receptor gene expression in the adult rat dorsal striatum following a 2 week unilateral cerebral decortication or pharmacological treatment with MK-801 was investigated by quantitative in situ hybridization. The caudate-putamen on the side of the cerebral decortication contains about 30% significantly lower mRNA levels than the control. In addition, we observed a 52% significant decrease in THC receptor mRNA levels in intact dorsal striatum after treatment with MK-801. Together these results suggest that in vivo, through the NMDA receptor subtype, glutamate up-regulates THC receptor gene expression in the rat caudate-putamen.

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Year:  1994        PMID： 8157073     DOI： 10.1016/0922-4106(94)90110-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

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Review 4.  Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.

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5.  Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism.

Authors:  Salvador Sierra; Natasha Luquin; Alberto J Rico; Virginia Gómez-Bautista; Elvira Roda; Iria G Dopeso-Reyes; Alfonso Vázquez; Eva Martínez-Pinilla; José L Labandeira-García; Rafael Franco; José L Lanciego
Journal:  Brain Struct Funct       Date:  2014-06-28       Impact factor: 3.270
  5 in total

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