Literature DB >> 8156386

Dopamine depletion in nigrostriatal neurons in the genetically diabetic rat.

T Kono1, M Takada.   

Abstract

Employing tyrosine hydroxylase (TH) immunohistochemistry, we have revealed that the enzyme is depleted in nigrostriatal neurons in the genetically diabetic BB Wistar (BBWd) rat. A similar, but much less marked reduction in TH immunoreactivity occurred in the mesolimbic dopamine system, which arises from the ventral tegmental area and terminates in the nucleus accumbens. The projection to the olfactory tubercle appeared unaffected. Since the decreased levels of dopamine in the mesencephalic dopamine systems could not be restored under insulin-controlled conditions, the impairment of dopamine biosynthesis in the BBWd rat may be genetically programmed.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8156386     DOI： 10.1016/0006-8993(94)90269-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Striatal dopaminergic D1 and D2 receptors after intracerebroventricular application of alloxan and streptozocin in rat.

Authors:  M Salković; I Sabolić; Z Lacković
Journal:  J Neural Transm Gen Sect       Date:  1995

2.  Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes.

Authors:  Rodrigo B Mansur; Gabriel R Fries; Mehala Subramaniapillai; Sophia Frangou; Fernanda G De Felice; Natalie Rasgon; Bruce McEwen; Elisa Brietzke; Roger S McIntyre
Journal:  J Psychiatr Res       Date:  2018-10-27       Impact factor: 4.791

3.  Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia.

Authors:  Fernando Caravaggio; Margaret Hahn; Shinichiro Nakajima; Philip Gerretsen; Gary Remington; Ariel Graff-Guerrero
Journal:  Med Hypotheses       Date:  2015-06-24       Impact factor: 1.538

4.  Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes.

Authors:  Bryan Cruz; Rodolfo J Flores; Kevin P Uribe; Evangelina J Espinoza; Charles T Spencer; Katherine M Serafine; Arbi Nazarian; Laura E O'Dell
Journal:  Neuropsychopharmacology       Date:  2019-01-07       Impact factor: 7.853

Review 5.  Brain insulin dysregulation: implication for neurological and neuropsychiatric disorders.

Authors:  Rasoul Ghasemi; Leila Dargahi; Ali Haeri; Maryam Moosavi; Zahurin Mohamed; Abolhassan Ahmadiani
Journal:  Mol Neurobiol       Date:  2013-01-20       Impact factor: 5.590

6.  Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of healthy nonobese humans.

Authors:  Fernando Caravaggio; Carol Borlido; Margaret Hahn; Zhe Feng; Gagan Fervaha; Philip Gerretsen; Shinichiro Nakajima; Eric Plitman; Jun Ku Chung; Yusuke Iwata; Alan Wilson; Gary Remington; Ariel Graff-Guerrero
Journal:  Int J Neuropsychopharmacol       Date:  2015-02-25       Impact factor: 5.176

Review 7.  Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction.

Authors:  Francesca Chiara Pignalosa; Antonella Desiderio; Paola Mirra; Cecilia Nigro; Giuseppe Perruolo; Luca Ulianich; Pietro Formisano; Francesco Beguinot; Claudia Miele; Raffaele Napoli; Francesca Fiory
Journal:  Int J Mol Sci       Date:  2021-11-16       Impact factor: 5.923

8.  Visual stimulation with food pictures in the regulation of hunger hormones and nutrient deposition, a potential contributor to the obesity crisis.

Authors:  Kalina Duszka; András Gregor; Martin Willibald Reichel; Andreas Baierl; Christine Fahrngruber; Jürgen König
Journal:  PLoS One       Date:  2020-04-24       Impact factor: 3.240
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.