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Literature DB >> 8156247

Is the pharmacological treatment of cancer cachexia possible?

Abstract

Cancer cachexia is highly prevalent in patients with advanced cancer. Its main clinical manifestation is profound anorexia. Progestational drugs have shown meaningful effects on appetite, food intake, and nutritional status in patients with advanced cancer and AIDS, and could be useful in managing anorexia. Corticosteroids also seem to produce increased appetite, but these effects are short-lived. Cyproheptadine, hydrazine sulfate, and cannabinoids also are being studied in the management of cancer-induced anorexia, but their role has not yet been clearly established. Future research should evaluate how the different drugs affect specific symptoms associated with cachexia.

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Year: 1993 PMID： 8156247 DOI： 10.1007/bf00364967

Source DB: PubMed Journal: Support Care Cancer ISSN： 0941-4355 Impact factor: 3.603

44 in total

1. Preoperative parenteral feeding in patients with gastrointestinal carcinoma.

Authors: J M Müller; U Brenner; C Dienst; H Pichlmaier
Journal: Lancet Date: 1982-01-09 Impact factor: 79.321

2. Trial of hydrazine sulfate (NSC-150014) in patients with cancer.

Authors: M Ochoa; R E Wittes; I H Krakoff
Journal: Cancer Chemother Rep Date: 1975 Nov-Dec

3. Workshop report. Psychopharmacologic applications to cancer.

Authors: L R Derogatis; R N MacDonald
Journal: Cancer Date: 1982-11-01 Impact factor: 6.860

4. A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer.

Authors: E Bruera; K Macmillan; N Kuehn; J Hanson; R N MacDonald
Journal: Cancer Date: 1990-09-15 Impact factor: 6.860

Review 5. Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.

Authors: C L Loprinzi; N M Ellison; R M Goldberg; J C Michalak; P A Burch
Journal: Semin Oncol Date: 1990-12 Impact factor: 4.929

6. Effect of hydrazine sulfate on glucose-regulating enzymes in the normal and cancerous rat.

Authors: R Silverstein; P Bhatia; D J Svoboda
Journal: Immunopharmacology Date: 1989 Jan-Feb

7. High-dose megestrol acetate. A possible treatment for cachexia.

Authors: N S Tchekmedyian; N Tait; M Moody; J Aisner
Journal: JAMA Date: 1987-03-06 Impact factor: 56.272

8. Clinical study of hydrazine sulfate in advanced cancer patients.

Authors: E Spremulli; G L Wampler; W Regelson
Journal: Cancer Chemother Pharmacol Date: 1979 Impact factor: 3.333

9. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group.

Authors: W D Dewys; C Begg; P T Lavin; P R Band; J M Bennett; J R Bertino; M H Cohen; H O Douglass; P F Engstrom; E Z Ezdinli; J Horton; G J Johnson; C G Moertel; M M Oken; C Perlia; C Rosenbaum; M N Silverstein; R T Skeel; R W Sponzo; D C Tormey
Journal: Am J Med Date: 1980-10 Impact factor: 4.965

10. Methylprednisolone as palliative therapy for female terminal cancer patients. The Methylprednisolone Female Preterminal Cancer Study Group.

Authors: T Popiela; R Lucchi; F Giongo
Journal: Eur J Cancer Clin Oncol Date: 1989-12

5 in total

Is the pharmacological treatment of cancer cachexia possible?

1. Preoperative parenteral feeding in patients with gastrointestinal carcinoma.

2. Trial of hydrazine sulfate (NSC-150014) in patients with cancer.

3. Workshop report. Psychopharmacologic applications to cancer.

4. A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer.

Review 5. Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.

6. Effect of hydrazine sulfate on glucose-regulating enzymes in the normal and cancerous rat.

7. High-dose megestrol acetate. A possible treatment for cachexia.

8. Clinical study of hydrazine sulfate in advanced cancer patients.

9. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group.

10. Methylprednisolone as palliative therapy for female terminal cancer patients. The Methylprednisolone Female Preterminal Cancer Study Group.

1. Nutrition in cancer patients: frustrating neglect and permanent challenge.

2. Fighting cancer cachexia--what about today's armory?

3. Corticosteroid prescribing in palliative care settings: a retrospective analysis in New Zealand.

4. Corticosteroids in palliative care - perspectives of clinicians involved in prescribing: a qualitative study.

Review 5. Adipose Tissue and Cancer Cachexia: What Nurses Need to Know.