| Literature DB >> 8155676 |
A Lacampagne1, F Gannier, J Argibay, D Garnier, J Y Le Guennec.
Abstract
We show that gadolinium (Gd3+) is a potent calcium channel blocker in guinea-pig isolated ventricular myocytes. A dose-dependent inhibition of ICaL was found with an EC50 of 1.4 microM and a complete inhibition at 10 microM Gd3+. When compared with Cd2+, it appeared that the blockade of ICaL is a complex phenomenon probably involving more than one site of interaction (a Hill coefficient of 1.6 was found for Gd3+ vs. 1.0 for Cd2+). It is concluded that Gd3+ ions completely block ICaL at concentrations used to block stretch-activated channels (SAC), rendering its use as a specific SAC inhibitor problematic.Entities:
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Year: 1994 PMID： 8155676 DOI： 10.1016/0005-2736(94)90250-x
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002