OBJECTIVES: To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS: HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. RESULTS: No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. CONCLUSIONS: These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.
OBJECTIVES: To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS:HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. RESULTS: No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. CONCLUSIONS: These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.
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Authors: M Galeazzi; G D Sebastiani; G Passiu; G Angelini; L Delfino; R A Asherson; M A Khamashta; G R Hughes Journal: J Rheumatol Date: 1992-01 Impact factor: 4.666
Authors: Z Yao; K Hartung; H G Deicher; G Brünnler; M P Bettinotti; E Keller; C Paul; C Gawron; S Mikschl; E Albert Journal: Eur J Immunogenet Date: 1993-08
Authors: J R Batchelor; A H Fielder; M J Walport; J David; D K Lord; N Davey; I A Dodi; P Malasit; W Wanachiwanawin; R Bernstein Journal: Clin Exp Immunol Date: 1987-11 Impact factor: 4.330