| Literature DB >> 8154878 |
A I Vermersch1, S Rivaud, M Vidailhet, A M Bonnet, B Gaymard, Y Agid, C Pierrot-Deseilligny.
Abstract
Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., "on") and without (i.e., "off") levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the "off" state, but significantly improved during the "on" period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.Entities:
Mesh：
Year: 1994 PMID： 8154878 DOI： 10.1002/ana.410350419
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422