BACKGROUND: X-linked lymphoproliferative disease is a hereditary disease that renders the males susceptible to fatal infectious mononucleosis, aplastic anemia, malignant lymphoma, and hypogammaglobulinemia after infection by the Epstein-Barr virus. METHODS: The authors examined the clinical and pathologic findings in an 8-year-old boy with bilateral retinal necrosis who died with aplastic anemia as a complication of X-linked lymphoproliferative disease. RESULTS: Results of histopathologic examination of the eyes disclosed retinal necrosis, and examination using the polymerase chain reaction technique showed Epstein-Barr virus genomic DNA in the left eye. CONCLUSION: Retinal necrosis may be part of the expanding spectrum of X-linked lymphoproliferative disease. It is unknown if the retinal necrosis is due directly to Epstein-Barr virus infection or a host inflammatory response.
BACKGROUND:X-linked lymphoproliferative disease is a hereditary disease that renders the males susceptible to fatal infectious mononucleosis, aplastic anemia, malignant lymphoma, and hypogammaglobulinemia after infection by the Epstein-Barr virus. METHODS: The authors examined the clinical and pathologic findings in an 8-year-old boy with bilateral retinal necrosis who died with aplastic anemia as a complication of X-linked lymphoproliferative disease. RESULTS: Results of histopathologic examination of the eyes disclosed retinal necrosis, and examination using the polymerase chain reaction technique showed Epstein-Barr virus genomic DNA in the left eye. CONCLUSION:Retinal necrosis may be part of the expanding spectrum of X-linked lymphoproliferative disease. It is unknown if the retinal necrosis is due directly to Epstein-Barr virus infection or a host inflammatory response.
Authors: J V Ongkosuwito; A Van der Lelij; M Bruinenberg; M Wienesen-van Doorn; E J Feron; C B Hoyng; R J de Keizer; A M Klok; A Kijlstra Journal: Br J Ophthalmol Date: 1998-03 Impact factor: 4.638
Authors: Kawsar R Talaat; Jennifer A Rothman; Jeffrey I Cohen; Mariarita Santi; John K Choi; Miguel Guzman; Robert Zimmerman; Sudha Nallasamy; Alexander Brucker; Martha Quezado; Stefania Pittaluga; Nicholas J Patronas; Amy D Klion; Kim E Nichols Journal: Pediatr Blood Cancer Date: 2009-12 Impact factor: 3.167