Literature DB >> 8152607

Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease.

H Akiyama1, K Ikeda, H Kondo, M Kato, P L McGeer.   

Abstract

Localization of type 2 plasminogen activator inhibitor (PAI-2) was investigated immunohistochemically in postmortem brain tissue of control subjects and patients with Alzheimer's disease (AD). Both the mouse monoclonal and the goat polyclonal antibodies to PAI-2 stained microglia. Reactive microglia were stained more intensely than resting microglia. PAI-2 may regulate the plasminogen activators and plasmin system in lesions of AD. It is suggested that PAI-2 plays a role for cell migration and matrix breakdown as well as for aberrant neurite outgrowth in senile plaques where persistent microglial activation is observed.

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Year:  1993        PMID： 8152607     DOI： 10.1016/0304-3940(93)90899-v

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  12 in total

1.  The plasmin system is induced by and degrades amyloid-beta aggregates.

Authors:  H M Tucker; M Kihiko; J N Caldwell; S Wright; T Kawarabayashi; D Price; D Walker; S Scheff; J P McGillis; R E Rydel; S Estus
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

2.  Comprehensive gene expression profiling reveals synergistic functional networks in cerebral vessels after hypertension or hypercholesterolemia.

Authors:  Wei-Yi Ong; Mary Pei-Ern Ng; Sau-Yeen Loke; Shalai Jin; Ya-Jun Wu; Kazuhiro Tanaka; Peter Tsun-Hon Wong
Journal:  PLoS One       Date:  2013-07-16       Impact factor: 3.240

3.  Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif.

Authors:  Grant A Darnell; Toni M Antalis; Ricky W Johnstone; Brett W Stringer; Steven M Ogbourne; David Harrich; Andreas Suhrbier
Journal:  Mol Cell Biol       Date:  2003-09       Impact factor: 4.272

4.  Genetic interactions associated with 12-month atrophy in hippocampus and entorhinal cortex in Alzheimer's Disease Neuroimaging Initiative.

Authors:  Shashwath A Meda; Mary Ellen I Koran; Jennifer R Pryweller; Jennifer N Vega; Tricia A Thornton-Wells
Journal:  Neurobiol Aging       Date:  2012-10-27       Impact factor: 4.673

Review 5.  Heparin oligosaccharides as potential therapeutic agents in senile dementia.

Authors:  Qing Ma; Umberto Cornelli; Israel Hanin; Walter P Jeske; Robert J Linhardt; Jeanine M Walenga; Jawed Fareed; John M Lee
Journal:  Curr Pharm Des       Date:  2007       Impact factor: 3.116

6.  Genome-wide association and interaction studies of CSF T-tau/Aβ42 ratio in ADNI cohort.

Authors:  Jin Li; Qiushi Zhang; Feng Chen; Xianglian Meng; Wenjie Liu; Dandan Chen; Jingwen Yan; Sungeun Kim; Lei Wang; Weixing Feng; Andrew J Saykin; Hong Liang; Li Shen
Journal:  Neurobiol Aging       Date:  2017-05-15       Impact factor: 5.133

7.  Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.

Authors:  Jin Li; Qiushi Zhang; Feng Chen; Jingwen Yan; Sungeun Kim; Lei Wang; Weixing Feng; Andrew J Saykin; Hong Liang; Li Shen
Journal:  Biomed Res Int       Date:  2015-09-03       Impact factor: 3.411

8.  SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.

Authors:  Jodi A Lee; Justin J Yerbury; Natalie Farrawell; Robert F Shearer; Patrick Constantinescu; Danny M Hatters; Wayne A Schroder; Andreas Suhrbier; Mark R Wilson; Darren N Saunders; Marie Ranson
Journal:  PLoS One       Date:  2015-06-17       Impact factor: 3.240

9.  Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.

Authors:  K E Hopperton; D Mohammad; M O Trépanier; V Giuliano; R P Bazinet
Journal:  Mol Psychiatry       Date:  2017-12-12       Impact factor: 15.992

Review 10.  Dysfunction in the coagulation system and schizophrenia.

Authors:  S Hoirisch-Clapauch; O B Amaral; M A U Mezzasalma; R Panizzutti; A E Nardi
Journal:  Transl Psychiatry       Date:  2016-01-05       Impact factor: 6.222
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