Literature DB >> 8152592

Low-threshold calcium current in dendrites of the adult rat hippocampus.

H Karst1, M Joëls, W J Wadman.   

Abstract

The patch-clamp technique was employed in hippocampal slices to examine the characteristics of a low-threshold Ca current in adult CA1 pyramidal neurons. We found that adult CA1 pyramidal neurons possess a distinct transient low-threshold Ca current, located predominantly in the distal dendrites. Surgical cuts that separated the dendrites from the soma and left a dendritic length of 150 microns, completely abolished the low-threshold Ca current while a transient K current persisted even in cells with dendrites as short as 50 microns. The transient low-threshold Ca current in dendrites may represent a voltage-dependent Ca entry pathway which contributes to the regulation of cellular excitability, plasticity and pathology.

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Year:  1993        PMID： 8152592     DOI： 10.1016/0304-3940(93)90880-t

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  19 in total

Review 1.  Dendritic low-threshold Ca2+ channels in rat cerebellar Purkinje cells: possible physiological implications.

Authors:  Pauline Cavelier; Jean-Louis Bossu
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Review 2.  Low-voltage-activated ("T-Type") calcium channels in review.

Authors:  Anne Marie R Yunker; Maureen W McEnery
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

3.  Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis.

Authors:  Yoel Yaari; Cuiyong Yue; Hailing Su
Journal:  J Physiol       Date:  2007-02-01       Impact factor: 5.182

4.  Seizure-like afterdischarges simulated in a model neuron.

Authors:  H Kager; W J Wadman; G G Somjen
Journal:  J Comput Neurosci       Date:  2007-04       Impact factor: 1.621

Review 5.  Ca(2+) signaling by T-type Ca(2+) channels in neurons.

Authors:  Lucius Cueni; Marco Canepari; John P Adelman; Anita Lüthi
Journal:  Pflugers Arch       Date:  2008-09-11       Impact factor: 3.657

6.  Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption.

Authors:  W Hesen; H Karst; O Meijer; T J Cole; W Schmid; E R de Kloet; G Schütz; M Joëls
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167

7.  Corticosteroid regulation of ion channel conductances and mRNA levels in individual hippocampal CA1 neurons.

Authors:  S M Nair; T R Werkman; J Craig; R Finnell; M Joëls; J H Eberwine
Journal:  J Neurosci       Date:  1998-04-01       Impact factor: 6.167

8.  Dendritic low-threshold calcium currents in thalamic relay cells.

Authors:  A Destexhe; M Neubig; D Ulrich; J Huguenard
Journal:  J Neurosci       Date:  1998-05-15       Impact factor: 6.167

9.  Low-threshold Ca2+ currents in dendritic recordings from Purkinje cells in rat cerebellar slice cultures.

Authors:  D Mouginot; J L Bossu; B H Gähwiler
Journal:  J Neurosci       Date:  1997-01-01       Impact factor: 6.167

10.  Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron.

Authors:  G G Somjen; H Kager; W J Wadman
Journal:  J Comput Neurosci       Date:  2008-06-18       Impact factor: 1.621
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