Literature DB >> 81524

Slow axonal transport of neurofilament proteins: impairment of beta,beta'-iminodipropionitrile administration.

J W Griffin, P N Hoffman, A W Clark, P T Carroll, D L Price.   

Abstract

beta,beta'-Iminodipropionitrile (IDPN) administration prevented normal slow axonal transport of [35S]methionine- or [3H]leucine-labeled proteins in rat sciatic motor axons. Ultrastructural and electrophoretic studies showed that the neurofilament triplet proteins in particular were retained within the initial 5 millimeters of the axons, resulting in neurofilament-filled axonal swellings. Fast anterograde and retrograde axonal transport were not affected. The IDPN thus selectively impaired slow axonal transport. The neurofibrillary pathology in this model is the result of the defective slow transport of neurofilaments.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 81524     DOI： 10.1126/science.81524

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  63 in total

1.  Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons.

Authors:  Aidong Yuan; Takahiro Sasaki; Asok Kumar; Corrinne M Peterhoff; Mala V Rao; Ronald K Liem; Jean-Pierre Julien; Ralph A Nixon
Journal:  J Neurosci       Date:  2012-06-20       Impact factor: 6.167

2.  A newly recognized neurodegenerative disorder of horned hereford calves.

Authors:  C G Rousseaux; G G Klavano; E S Johnson; T K Shnitka; W N Harries
Journal:  Can Vet J       Date:  1983-09       Impact factor: 1.008

Review 3.  Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration.

Authors:  Rodolphe Perrot; Raphael Berges; Arnaud Bocquet; Joel Eyer
Journal:  Mol Neurobiol       Date:  2008-07-23       Impact factor: 5.590

4.  Models of environmentally induced neurological disease: epidemiology and etiology of amyotrophic lateral sclerosis and parkinsonism-dementia in the Western Pacific.

Authors:  R M Garruto; R Yanagihara; D C Gajdusek
Journal:  Environ Geochem Health       Date:  1990-03       Impact factor: 4.609

Review 5.  Axonal transport disruption in peripheral nerve disease: From Jack's discoveries as a resident to recent contributions.

Authors:  Thomas E Lloyd
Journal:  J Peripher Nerv Syst       Date:  2012-12       Impact factor: 3.494

6.  Aluminum-induced neurofibrillary changes in axons and dendrites.

Authors:  H M Wisniewski; J W Shek; S Gruca; J A Sturman
Journal:  Acta Neuropathol       Date:  1984       Impact factor: 17.088

Review 7.  Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review.

Authors:  Mala V Rao; Ralph A Nixon
Journal:  Neurochem Res       Date:  2003-07       Impact factor: 3.996

8.  An immunocytochemical comparison of cytoskeletal proteins in aluminum-induced and Alzheimer-type neurofibrillary tangles.

Authors:  D Munoz-Garcia; W W Pendlebury; J B Kessler; D P Perl
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

9.  Communicating hydrocephalus in rodents treated with beta,beta'-iminodipropionitrile (IDPN).

Authors:  M G Fiori; L R Sharer; H E Lowndes
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088

10.  Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis (ALS). Clinical studies in ALS of Guam and experimental studies in deafferented neurons and in beta,beta'-iminodipropionitrile axonopathy.

Authors:  Z Mourelatos; A Hirano; A C Rosenquist; N K Gonatas
Journal:  Am J Pathol       Date:  1994-06       Impact factor: 4.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.