Literature DB >> 8151795

A protease activation mutant, MVCES1, as a safe and potent live vaccine derived from currently prevailing Sendai virus.

X L Wang1, M Itoh, H Hotta, M Homma.   

Abstract

Sendai virus fresh isolates were shown to be antigenically different from the prototype Fushimi strain that had long been passaged in embryonated chicken eggs. Phylogenetic analysis of the hemagglutinin-neuraminidase genes also revealed the difference between these two virus groups. Both trypsin-resistant and elastase-sensitive mutations were additionally introduced to an LLC-MK2-cell-adapted and attenuated mutant derived from one of the fresh isolates. This protease activation mutant (MVCES1) showed the same antigenicity as the fresh isolates, and as a result of a single cycle of growth in lungs, it could confer better protection on mice against challenge infection with the currently prevailing Sendai virus than TR-5, which is a trypsin-resistant mutant derived from the Fushimi strain. The eligibility of MVCES1 as an attenuated live vaccine of Sendai virus is discussed.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8151795      PMCID： PMC236828     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  42 in total

1.  An epizootic of Sendai infection with mortality in a barrier-maintained mouse colony.

Authors:  P N Bhatt; A M Jonas
Journal:  Am J Epidemiol       Date:  1974-09       Impact factor: 4.897

2.  Identification of biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity of proteolytic cleavage of an inactive precursor protein of Sendai virus.

Authors:  A Scheid; P W Choppin
Journal:  Virology       Date:  1974-02       Impact factor: 3.616

3.  Trypsin action on the growth of Sendai virus in tissue culture cells. 3. Structural difference of Sendai viruses grown in eggs and tissue culture cells.

Authors:  M Homma; M Ouchi
Journal:  J Virol       Date:  1973-12       Impact factor: 5.103

4.  Restoration of the fusion activity of L cell-borne Sendai virus by trypsin.

Authors:  M Homma; S Tamagawa
Journal:  J Gen Virol       Date:  1973-06       Impact factor: 3.891

5.  Structural components of Sendai virus. Serological and physicochemical characterization of hemagglutinin subunit associated with neuraminidase activity.

Authors:  H Tozawa; M Watanabe; N Ishida
Journal:  Virology       Date:  1973-09       Impact factor: 3.616

6.  Trypsin action on the growth of Sendai virus in tissue culture cells. II. Restoration of the hemolytic activity if L cell-borne Sendai virus by trypsin.

Authors:  M Homma
Journal:  J Virol       Date:  1972-05       Impact factor: 5.103

7.  Trypsin action on the growth of Sendai virus in tissue culture cells. I. Restoration of the infectivity for L cells by direct action of tyrpsin on L cell-borne Sendai virus.

Authors:  M Homma
Journal:  J Virol       Date:  1971-11       Impact factor: 5.103

8.  Plaque formation by sendai virus of parainfluenza virus group, type 1 on monkey, calf kidney and chick embryo cell monolayers.

Authors:  H Shibuta; M Akami; M Matumoto
Journal:  Jpn J Microbiol       Date:  1971-03

9.  Enzootic sendai infection in laboratory hamsters.

Authors:  M L Profeta; F S Lief; S A Plotkin
Journal:  Am J Epidemiol       Date:  1969-03       Impact factor: 4.897

10.  Proteins and glycoproteins of paramyxoviruses: a comparison of simian virus 5, Newcastle disease virus, and Sendai virus.

Authors:  W E Mountcastle; R W Compans; P W Choppin
Journal:  J Virol       Date:  1971-01       Impact factor: 5.103
View more
  5 in total

1.  Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames.

Authors:  Y Fujii; K Kiyotani; T Yoshida; T Sakaguchi
Journal:  Virus Genes       Date:  2001-01       Impact factor: 2.332

2.  The various Sendai virus C proteins are not functionally equivalent and exert both positive and negative effects on viral RNA accumulation during the course of infection.

Authors:  P Latorre; T Cadd; M Itoh; J Curran; D Kolakofsky
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

3.  The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion.

Authors:  T Cadd; D Garcin; C Tapparel; M Itoh; M Homma; L Roux; J Curran; D Kolakofsky
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

4.  Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA.

Authors:  Yutaka Fujii; Takemasa Sakaguchi; Katsuhiro Kiyotani; Cheng Huang; Noriko Fukuhara; Yoshiko Egi; Tetsuya Yoshida
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

5.  Sendai virus targets inflammatory responses, as well as the interferon-induced antiviral state, in a multifaceted manner.

Authors:  Laura Strähle; Dominique Garcin; Philippe Le Mercier; Joerg F Schlaak; Daniel Kolakofsky
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.