Literature DB >> 8150710

Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D.

Y K Kim1, H Tomoda, H Nishida, T Sunazuka, R Obata, S Omura.   

Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

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Year:  1994        PMID： 8150710     DOI： 10.7164/antibiotics.47.154

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Insecticidal properties of pyripyropene A, a microbial secondary metabolite, against agricultural pests.

Authors:  Ryo Horikoshi; Kimihiko Goto; Masaaki Mitomi; Kazuhiko Oyama; Toshiaki Sunazuka; Satoshi Ōmura
Journal:  J Pestic Sci       Date:  2018-11-20       Impact factor: 1.519

2.  Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69.

Authors:  Zhuang Ding; Lianqing Zhang; Juan Fu; Qian Che; Dehai Li; Qianqun Gu; Tianjiao Zhu
Journal:  J Antibiot (Tokyo)       Date:  2015-06-10       Impact factor: 2.649

3.  New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.

Authors:  Taichi Ohshiro; Masaki Ohtawa; Tohru Nagamitsu; Daisuke Matsuda; Hiroaki Yagyu; Matthew A Davis; Lawrence L Rudel; Shun Ishibashi; Hiroshi Tomoda
Journal:  J Pharmacol Exp Ther       Date:  2015-09-03       Impact factor: 4.030

4.  In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.

Authors:  Daisuke Matsuda; Taichi Ohshiro; Masaki Ohtawa; Hiroyuki Yamazaki; Tohru Nagamitsu; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2014-07-09       Impact factor: 2.649

5.  Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species.

Authors:  H J Wang; J B Gloer; D T Wicklow; P F Dowd
Journal:  Appl Environ Microbiol       Date:  1995-12       Impact factor: 4.792

Review 6.  Angiosuppressive properties of marine-derived compounds-a mini review.

Authors:  Patrick Y K Yue; H M Leung; Adela J Li; Tracy N C Chan; T S Lum; Y L Chung; Y H Sung; M H Wong; Kelvin S Y Leung; Eddy Y Zeng
Journal:  Environ Sci Pollut Res Int       Date:  2015-10-31       Impact factor: 4.223

7.  Characterization of two acetyltransferase genes in the pyripyropene biosynthetic gene cluster from Penicillium coprobium.

Authors:  Jie Hu; Ayako Furutani; Kentaro Yamamoto; Kazuhiko Oyama; Masaaki Mitomi; Hiroyuki Anzai
Journal:  Biotechnol Biotechnol Equip       Date:  2014-10-31       Impact factor: 1.632

8.  Penicillium arizonense, a new, genome sequenced fungal species, reveals a high chemical diversity in secreted metabolites.

Authors:  Sietske Grijseels; Jens Christian Nielsen; Milica Randelovic; Jens Nielsen; Kristian Fog Nielsen; Mhairi Workman; Jens Christian Frisvad
Journal:  Sci Rep       Date:  2016-10-14       Impact factor: 4.379

9.  Synthesis of pyripyropene derivatives and their pest-control efficacy.

Authors:  Kimihiko Goto; Ryo Horikoshi; Satoshi Nakamura; Masaaki Mitomi; Kazuhiko Oyama; Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Ōmura
Journal:  J Pestic Sci       Date:  2019-07-25       Impact factor: 2.529

10.  Afidopyropen, a novel insecticide originating from microbial secondary extracts.

Authors:  Ryo Horikoshi; Kimihiko Goto; Masaaki Mitomi; Kazuhiko Oyama; Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Ōmura
Journal:  Sci Rep       Date:  2022-02-18       Impact factor: 4.379
  10 in total

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