Literature DB >> 8149954

Bimodal distribution of V beta 2+CD4+ T cells in human peripheral blood.

G R Clarke1, H Reyburn, F C Lancaster, A W Boylston.   

Abstract

The distribution of T cells using the V beta 2 gene was studied in a group of 99 humans. The distribution of V beta 2+CD4+ levels was bimodal. Twelve individuals had levels of V beta 2+CD4+ less than 2% and 86 others had values greater than 5%. Only one individual had a value between 2% and 5%. The V beta 2 low (mean 1.3 +/- 0.49) and V beta 2 high (mean 8.2 +/- 1.65) phenotypes were stable. The V beta 2 low phenotype is inherited and not limited to HLA or T cell receptor V beta gene complexes. The CD8V beta 2 levels of CD4V beta 2 low individuals are also low. The residual V beta 2+ T cells in V beta 2 low individuals were not anergic to V beta 2-specific stimulation. These data are compatible with the effects of an endogenous superantigen.

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Year:  1994        PMID： 8149954     DOI： 10.1002/eji.1830240410

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  7 in total

1.  Peripheral blood T lymphocytes in systemic vasculitis: increased T cell receptor V beta 2 gene usage in microscopic polyarteritis.

Authors:  I J Simpson; M A Skinner; A Geursen; J S Peake; W G Abbott; J D Fraser; C M Lockwood; P L Tan
Journal:  Clin Exp Immunol       Date:  1995-08       Impact factor: 4.330

Review 2.  The potential role of superantigens in inflammatory bowel disease.

Authors:  R A Kay
Journal:  Clin Exp Immunol       Date:  1995-04       Impact factor: 4.330

3.  Reactivity of mouse T-cell hybridomas expressing human Vbeta gene segments with staphylococcal and streptococcal superantigens.

Authors:  B Fleischer; A Necker; C Leget; B Malissen; F Romagne
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

4.  A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.

Authors:  N Nagvekar; A M Moody; P Moss; I Roxanis; J Curnow; D Beeson; N Pantic; J Newsom-Davis; A Vincent; N Willcox
Journal:  J Clin Invest       Date:  1998-05-15       Impact factor: 14.808

5.  Distribution and evolution of T-cell receptor Vbeta repertoire on peripheral blood lymphocytes of newborn infants of human immunodeficiency virus (HIV)-infected mothers: differential display on CD4 and CD8 T cells and effect of HIV infection.

Authors:  William Borkowsky; Song-He Chen; Ilana Belitskaya-Levy
Journal:  Clin Vaccine Immunol       Date:  2007-07-25

6.  Large granular lymphocyte expansions in patients with Felty's syndrome: analysis using anti-T cell receptor V beta-specific monoclonal antibodies.

Authors:  S J Bowman; M Bhavnani; G C Geddes; V Corrigall; A W Boylston; G S Panayi; J S Lanchbury
Journal:  Clin Exp Immunol       Date:  1995-07       Impact factor: 4.330

7.  Identification of class II major histocompatibility complex and T cell receptor binding sites in the superantigen toxic shock syndrome toxin 1.

Authors:  J M Hurley; R Shimonkevitz; A Hanagan; K Enney; E Boen; S Malmstrom; B L Kotzin; M Matsumura
Journal:  J Exp Med       Date:  1995-06-01       Impact factor: 14.307
  7 in total

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