Comparative bioequivalence study of different brands of acetyl salicylic acid in human volunteers.

A double blind cross over randomized study was conducted in 7 normal healthy volunteers. Single dose (700 mg) of buffered aspirin or aspirin with calcium carbonate or aspirin with caffeine was administered orally, at least 3 days apart. Blood samples were drawn at different time intervals after administration of drug for estimation of salicylate levels. The values of different pharmacokinetic parameters (AUC0-infinity, Cmax and tmax) did not show any significant difference, suggesting that these three brands of aspirin are biologically equivalent.

RCT Entities:   Population Interventions Outcomes