Literature DB >> 8149769

Generalizing the results of randomized clinical trials.

K R Bailey1.   

Abstract

Many scientific and statistical issues are involved in generalizing the results of randomized clinical trials. This paper examines the issues of heterogeneity of risk and heterogeneity of effect, as well as quantitative vs. qualitative heterogeneity. Generalization of quantitative results to populations at different risk is shown to be problematic, independent of any other considerations. Issues of heterogeneity as they relate to target population and choice of therapy are discussed. A few proposals are offered regarding the design and report of trials.

Mesh：

Year:  1994        PMID： 8149769     DOI： 10.1016/0197-2456(94)90024-8

Source DB:  PubMed          Journal:  Control Clin Trials        ISSN： 0197-2456


  18 in total

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3.  Surgical outcomes research based on administrative data: inferior or complementary to prospective randomized clinical trials?

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4.  The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.

Authors:  S H Downs; N Black
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Review 5.  Getting research findings into practice. When to act on the evidence.

Authors:  T A Sheldon; G H Guyatt; A Haines
Journal:  BMJ       Date:  1998-07-11

6.  Cost-effectiveness analysis of enoxaparin versus unfractionated heparin in the secondary prevention of acute coronary syndrome.

Authors:  Max Brosa; Carlos Rubio-Terrés; Ibrahim Farr; Vijay Nadipelli; Jenaro Froufe
Journal:  Pharmacoeconomics       Date:  2002       Impact factor: 4.981

Review 7.  'Lost in translation': accounting for between-country differences in the analysis of multinational cost-effectiveness data.

Authors:  Andrea Manca; Andrew R Willan
Journal:  Pharmacoeconomics       Date:  2006       Impact factor: 4.981

8.  The "1-year-death number needed to treat" for comparing the impact of distinct interventions on patient outcomes.

Authors:  Brett N Hryciw; Finlay A McAlister; Meltem Tuna; Carl van Walraven
Journal:  CMAJ       Date:  2019-11-11       Impact factor: 8.262

Review 9.  MRC quality of life studies using a daily diary card--practical lessons learned from cancer trials.

Authors:  P Fayers
Journal:  Qual Life Res       Date:  1995-08       Impact factor: 4.147

10.  Does the type of weight loss diet affect who participates in a behavioral weight loss intervention? A comparison of participants for a plant-based diet versus a standard diet trial.

Authors:  Gabrielle M Turner-McGrievy; Charis R Davidson; Sara Wilcox
Journal:  Appetite       Date:  2013-11-20       Impact factor: 3.868
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