Literature DB >> 8149348

Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol.

Z Ren1, M N Gould.   

Abstract

Monoterpenes such as perillyl alcohol have been shown to cause the complete regression of advanced mammary carcinomas. Given the common origin of plant monoterpenes and many important molecules in mammalian mevalonate metabolism pathway, we investigated the effects of the monoterpene perillyl alcohol on mevalonate metabolism. NIH3T3 cells were labeled with [14C]mevalonolactone and lipids were analyzed. Perillyl alcohol inhibited ubiquinone synthesis and blocked the conversion of lathosterol to cholesterol. These two cellular effects of perillyl alcohol may contribute to the antitumor activity of the monoterpenes.

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Year:  1994        PMID： 8149348     DOI： 10.1016/0304-3835(94)90396-4

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

Review 1.  Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway.

Authors:  D W End
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

Review 2.  Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy.

Authors:  Thomas C Chen; Clovis O Da Fonseca; Axel H Schönthal
Journal:  Am J Cancer Res       Date:  2015-04-15       Impact factor: 6.166

3.  CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.

Authors:  Vincent Courdavault; Martine Thiersault; Martine Courtois; Pascal Gantet; Audrey Oudin; Pierre Doireau; Benoit St-Pierre; Nathalie Giglioli-Guivarc'h
Journal:  Plant Mol Biol       Date:  2005-04       Impact factor: 4.076

4.  Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.

Authors:  S R Cerda; J Wilkinson; S K Branch; S A Broitman
Journal:  Lipids       Date:  1999-06       Impact factor: 1.880

5.  Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol.

Authors:  Y D Burke; M J Stark; S L Roach; S E Sen; P L Crowell
Journal:  Lipids       Date:  1997-02       Impact factor: 1.880

6.  S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation.

Authors:  Alexandre Huchelmann; Clément Gastaldo; Mickaël Veinante; Ying Zeng; Dimitri Heintz; Denis Tritsch; Hubert Schaller; Michel Rohmer; Thomas J Bach; Andréa Hemmerlin
Journal:  Plant Physiol       Date:  2013-12-23       Impact factor: 8.340

7.  Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene.

Authors:  J D Haag; M N Gould
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

Review 8.  Cancer chemoprevention and therapy by monoterpenes.

Authors:  M N Gould
Journal:  Environ Health Perspect       Date:  1997-06       Impact factor: 9.031

Review 9.  Antitumor activity of monoterpenes found in essential oils.

Authors:  Marianna Vieira Sobral; Aline Lira Xavier; Tamires Cardoso Lima; Damião Pergentino de Sousa
Journal:  ScientificWorldJournal       Date:  2014-10-14

10.  Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation.

Authors:  A Komori; S Okabe; M Suganuma; M A Kerr; J Busch-Petersen; L M Oh; J Zhuo; G S Kannangara; X Zou; M A Tius; H Fujiki
Journal:  Jpn J Cancer Res       Date:  1996-09
  10 in total

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