Literature DB >> 8148378

Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.

K Yokoyama1, H Suzuki, K Yasumoto, Y Tomita, S Shibahara.   

Abstract

We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart.

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Year:  1994        PMID： 8148378     DOI： 10.1016/0167-4781(94)90292-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  21 in total

1.  Molecular mapping of epitopes on melanocyte-specific protein Pmel17 which are recognized by autoantibodies in patients with vitiligo.

Authors:  E H Kemp; E A Waterman; D J Gawkrodger; P F Watson; A P Weetman
Journal:  Clin Exp Immunol       Date:  2001-06       Impact factor: 4.330

2.  Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.

Authors:  Irit Adini; Kaustabh Ghosh; Avner Adini; Zai-Long Chi; Takeru Yoshimura; Ofra Benny; Kip M Connor; Michael S Rogers; Lauren Bazinet; Amy E Birsner; Diane R Bielenberg; Robert J D'Amato
Journal:  J Clin Invest       Date:  2013-12-20       Impact factor: 14.808

3.  STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.

Authors:  Yuichi Sekine; Sumihito Togi; Ryuta Muromoto; Shigeyuki Kon; Yuichi Kitai; Akihiko Yoshimura; Kenji Oritani; Tadashi Matsuda
Journal:  J Biol Chem       Date:  2015-05-28       Impact factor: 5.157

4.  Transcriptional activation of tyrosinase gene by human placental sphingolipid.

Authors:  Bidisha Saha; Suman Kumar Singh; Chinmoy Sarkar; Shampa Mallick; Rabindranath Bera; Ranjan Bhadra
Journal:  Glycoconj J       Date:  2006-05       Impact factor: 2.916

5.  Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.

Authors:  C Bertolotto; R Buscà; P Abbe; K Bille; E Aberdam; J P Ortonne; R Ballotti
Journal:  Mol Cell Biol       Date:  1998-02       Impact factor: 4.272

6.  Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy.

Authors:  Hung T Khong; Steven A Rosenberg
Journal:  J Immunol       Date:  2002-01-15       Impact factor: 5.422

7.  Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene.

Authors:  K Yasumoto; K Yokoyama; K Shibata; Y Tomita; S Shibahara
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

8.  p38 regulates pigmentation via proteasomal degradation of tyrosinase.

Authors:  Barbara Bellei; Vittoria Maresca; Enrica Flori; Angela Pitisci; Lionel Larue; Mauro Picardo
Journal:  J Biol Chem       Date:  2010-01-06       Impact factor: 5.157

9.  Autoantibodies to human melanocyte-specific protein pmel17 in the sera of vitiligo patients: a sensitive and quantitative radioimmunoassay (RIA).

Authors:  E H Kemp; D J Gawkrodger; P F Watson; A P Weetman
Journal:  Clin Exp Immunol       Date:  1998-12       Impact factor: 4.330

10.  Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.

Authors:  Y T Chen; E Stockert; S Tsang; K A Coplan; L J Old
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205
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