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Literature DB >> 8147894

Thyroid hormone influences beta myosin heavy chain (beta MHC) expression.

J G Edwards¹, J J Bahl, I L Flink, S Y Cheng, E Morkin.

Abstract

3,5,3'-Triiodo-L-thyronine (T3) regulation of beta-MHC expression was studied in rat fetal heart cells using deletion mutants of both the rat and human promoter regions fused to a CAT expression vector. T3 inhibited the expression of human and rat beta-MHC constructs with an IC50 of about 1nM, which was similar to the EC50 for beta MHC-mRNA observed in cardiomyocytes. Deletion analysis of beta MHC promoter constructs suggested that a T3 response element (TRE) is located near the start of transcription. Possibly, T3-receptor binding at this site interferes with formation of the transcriptional initiation complex.

Entities: Chemical Gene Species

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Year: 1994 PMID： 8147894 DOI： 10.1006/bbrc.1994.1398

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

20 in total

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2. G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential.

Authors: K Kaur; J Yang; J G Edwards; C A Eisenberg; L M Eisenberg
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Review 3. Role of thyroid hormones in ventricular remodeling.

Authors: Viswanathan Rajagopalan; A Martin Gerdes
Journal: Curr Heart Fail Rep Date: 2015-04

4. AFos dissociates cardiac myocyte hypertrophy and expression of the pathological gene program.

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6. The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.

Authors: Karin Wallis; Susi Dudazy; Max van Hogerlinden; Kristina Nordström; Jens Mittag; Björn Vennström
Journal: Mol Endocrinol Date: 2010-08-25

Thyroid hormone influences beta myosin heavy chain (beta MHC) expression.

1. Chronic ethanol consumption increases myocardial mitochondrial DNA mutations: a potential contribution by mitochondrial topoisomerases.

2. G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential.

Review 3. Role of thyroid hormones in ventricular remodeling.

4. AFos dissociates cardiac myocyte hypertrophy and expression of the pathological gene program.

5. Effects of weight loss and leptin on skeletal muscle in human subjects.

6. The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.

7. Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity.

8. Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications.

9. Promoter analysis of ventricular myosin heavy chain (vmhc) in zebrafish embryos.

10. Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.