OBJECTIVE: This study was designed to test the hypothesis that patients with both major depressive disorder and panic disorder exhibit more clinical symptoms and have a more protracted course of illness than patients with major depressive disorder only. METHOD: The authors compared standardized clinical evaluations (from Schedule for Affective Disorders and Schizophrenia interviews) of 119 patients with major depressive disorder only and 57 patients with major depressive disorder and concurrent panic disorder. Clinical and demographic variables were included. RESULTS: The patients with both disorders reported symptoms of major depressive disorder earlier in life and also required treatment and hospital admission earlier in life. Many clinical features during the index episode were significantly more severe in the patients with both disorders. A logistic regression identified a "panic index" consisting of the symptoms of somatic anxiety, phobia, indecisiveness, and feelings of inadequacy. Scores on this index allowed proper classification of patients to either of the two diagnostic groups with high reliability. CONCLUSIONS: In major depressive disorder, the presence of panic disorder is suggestive of a more severe and precocious form of illness.
OBJECTIVE: This study was designed to test the hypothesis that patients with both major depressive disorder and panic disorder exhibit more clinical symptoms and have a more protracted course of illness than patients with major depressive disorder only. METHOD: The authors compared standardized clinical evaluations (from Schedule for Affective Disorders and Schizophrenia interviews) of 119 patients with major depressive disorder only and 57 patients with major depressive disorder and concurrent panic disorder. Clinical and demographic variables were included. RESULTS: The patients with both disorders reported symptoms of major depressive disorder earlier in life and also required treatment and hospital admission earlier in life. Many clinical features during the index episode were significantly more severe in the patients with both disorders. A logistic regression identified a "panic index" consisting of the symptoms of somatic anxiety, phobia, indecisiveness, and feelings of inadequacy. Scores on this index allowed proper classification of patients to either of the two diagnostic groups with high reliability. CONCLUSIONS: In major depressive disorder, the presence of panic disorder is suggestive of a more severe and precocious form of illness.
Authors: Jill M Cyranowski; Laura L Schott; Howard M Kravitz; Charlotte Brown; Rebecca C Thurston; Hadine Joffe; Karen A Matthews; Joyce T Bromberger Journal: Depress Anxiety Date: 2012-08-28 Impact factor: 6.505
Authors: William Coryell; David A Solomon; Jess G Fiedorowicz; Jean Endicott; Pamela J Schettler; Lewis L Judd Journal: Am J Psychiatry Date: 2009-10-01 Impact factor: 18.112
Authors: Y Li; S Shi; F Yang; J Gao; Youhui Li; M Tao; G Wang; K Zhang; C Gao; L Liu; Kan Li; Keqing Li; Y Liu; Xumei Wang; J Zhang; L Lv; Xueyi Wang; Q Chen; J Hu; L Sun; J Shi; Y Chen; D Xie; J Flint; K S Kendler; Z Zhang Journal: Psychol Med Date: 2011-11-30 Impact factor: 7.723
Authors: Cristina Toni; Giulio Perugi; Franco Frare; Giuseppe Tusini; Konstantinos N Fountoulakis; Kareen K Akiskal; Hagop S Akiskal Journal: Ann Gen Psychiatry Date: 2008-11-13 Impact factor: 3.455