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Literature DB >> 8145192

Modulation of K(+)-channels in p-neurones of the leech CNS by phosphorylation.

Abstract

Two types of potassium channels of identified (p-) neurones of the leech (Hirudo medicinalis) were investigated by using the patch-clamp technique. The open-state probability of these channels in cell-attached patches can be reduced by addition of 5-hydroxytryptamine to the bath solution. After excising the patches the application of alkaline phosphatase to the cytosolic face of the patch increases the open probability. The 5-HT1A-receptor agonist buspirone mimics the effect of 5-HT. Our experiments show that the effect of 5-HT might be due to a channel phosphorylation via a 5-HT1A-receptor subtype.

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Year: 1994 PMID： 8145192 DOI： 10.1007/bf00193789

Source DB: PubMed Journal: J Comp Physiol A Impact factor: 1.836

15 in total

1. An annotated CNS transcriptome of the medicinal leech, Hirudo verbana: De novo sequencing to characterize genes associated with nervous system activity.

Authors: Adam J Northcutt; Eva K Fischer; Joshua G Puhl; Karen A Mesce; David J Schulz
Journal: PLoS One Date: 2018-07-20 Impact factor: 3.240

1 in total

Modulation of K(+)-channels in p-neurones of the leech CNS by phosphorylation.

1. Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A.

Review 2. Modulation of ion channels in neurons and other cells.

3. Specific modalities and receptive fields of sensory neurons in CNS of the leech.

4. Potassium distribution and membrane potential of sensory neurons in the leech nervous system.

5. Modulation of acetylcholine-activated K+ channel function in rat atrial cells by phosphorylation.

6. Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones.

7. POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.

8. The role of 5-hydroxytryptamine as a transmitter between identified leech neurones in culture.

9. Modulation of the serotonin-sensitive potassium channel in Aplysia sensory neurone cell body and growth cone.

10. Na+, K+ and Ca2+ currents in identified leech neurones in culture.

1. An annotated CNS transcriptome of the medicinal leech, Hirudo verbana: De novo sequencing to characterize genes associated with nervous system activity.