Literature DB >> 8144393

Increased expression of trk proto-oncogene by gamma-interferon in human neuroblastoma cell lines.

A Shikata1, T Sugimoto, H Hosoi, Y Sotozono, T Shikata, T Sawada, L F Parada.   

Abstract

Three human neuroblastoma cell lines were examined to determine the effect of recombinant gamma-interferon (IFN-gamma) treatment on the expression of trk proto-oncogene. Increased levels of trk proto-oncogene mRNA were observed in two neuroblastoma cell lines (KP-N-RT and KP-N-SI(FA)) after IFN-gamma treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time- and dose-dependent manner. The decreased level of N-myc mRNA after IFN-gamma treatment in KP-N-RT was inversely correlated with trk mRNA. Our results suggest that IFN-gamma can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8144393      PMCID： PMC5919423          DOI： 10.1111/j.1349-7006.1994.tb02070.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  23 in total

1.  The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.

Authors:  D R Kaplan; B L Hempstead; D Martin-Zanca; M V Chao; L F Parada
Journal:  Science       Date:  1991-04-26       Impact factor: 47.728

2.  Cell surface membrane antigen present on neuroblastoma cells but not fetal neuroblasts recognized by a monoclonal antibody (KP-NAC8).

Authors:  T Matsumura; T Sugimoto; T Sawada; T Amagai; S Negoro; J T Kemshead
Journal:  Cancer Res       Date:  1987-06-01       Impact factor: 12.701

3.  Number and organization of actin-related sequences in the mouse genome.

Authors:  A J Minty; S Alonso; J L Guénet; M E Buckingham
Journal:  J Mol Biol       Date:  1983-06-15       Impact factor: 5.469

4.  Neuroblastoma: inverse relationship between expression of N-myc and NGF-r.

Authors:  H Christiansen; N M Christiansen; F Wagner; M Altmannsberger; F Lampert
Journal:  Oncogene       Date:  1990-03       Impact factor: 9.867

5.  Expression and function of the nerve growth factor receptor (TRK-A) in human neuroblastoma cell lines.

Authors:  C G Azar; N J Scavarda; A Nakagawara; G M Brodeur
Journal:  Prog Clin Biol Res       Date:  1994

6.  Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.

Authors:  M Schwab; J Ellison; M Busch; W Rosenau; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

7.  Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression.

Authors:  R J Kaufman; P A Sharp
Journal:  Mol Cell Biol       Date:  1982-11       Impact factor: 4.272

8.  Inverse relationship between trk expression and N-myc amplification in human neuroblastomas.

Authors:  A Nakagawara; M Arima; C G Azar; N J Scavarda; G M Brodeur
Journal:  Cancer Res       Date:  1992-03-01       Impact factor: 12.701

9.  Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma.

Authors:  A Nakagawara; M Arima-Nakagawara; N J Scavarda; C G Azar; A B Cantor; G M Brodeur
Journal:  N Engl J Med       Date:  1993-03-25       Impact factor: 91.245

10.  Differential susceptibility of HLA class II antigens induced by gamma-interferon in human neuroblastoma cell lines.

Authors:  T Sugimoto; Y Horii; T Hino; J T Kemshead; H Kuroda; T Sawada; H Morioka; J Imanishi; H Inoko
Journal:  Cancer Res       Date:  1989-04-01       Impact factor: 12.701
View more
  4 in total

1.  Effects of gamma-IFN and NGF on subpopulations in a human neuroblastoma cell line: flow cytometric and morphological analysis.

Authors:  J Ridge; D A Terle; E Dragunsky; I Levenbook
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-04       Impact factor: 2.416

2.  Insulin-like growth factor II in the pathogenesis of human neuroblastoma.

Authors:  K A Sullivan; V P Castle; S M Hanash; E L Feldman
Journal:  Am J Pathol       Date:  1995-12       Impact factor: 4.307

3.  Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells.

Authors:  T Sugimoto; H Kuroda; Y Horii; H Moritake; T Tanaka; S Hattori
Journal:  Jpn J Cancer Res       Date:  2001-02

4.  Identification of human thioredoxin as a novel IFN-gamma-induced factor: mechanism of induction and its role in cytokine production.

Authors:  Seol-Hee Kim; Jiyoung Oh; Ja-Young Choi; Ji-Young Jang; Myoung-Wha Kang; Choong-Eun Lee
Journal:  BMC Immunol       Date:  2008-11-05       Impact factor: 3.615
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.