Literature DB >> 814368

Demonstration of carbohydrate structures in malignant melanoma tyrosinase.

W P Herrmann, G Uhlenbruck.   

Abstract

Electrophoretic studies on malignant melanoma extracts before and after treatment with neuraminidase revealed that tyrosinase is a glycoprotein containing N-acetyl-neuraminic acid. Double diffusion tests using Concanavalin A and the lectin from Ricinus communis show that the carbohydrated chain of tyrosinase contains D-mannose as a sugar unit located within the carbohydrate chain. The terminal neuraminic acid groups are linked to D-galactose. The enzymatic activity of tyrosinase is not inhibited by Concanavalin A.

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Year:  1976        PMID： 814368     DOI： 10.1007/BF01468775

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  4 in total

Review 1.  The biochemistry of plant lectins (phytohemagglutinins).

Authors:  H Lis; N Sharon
Journal:  Annu Rev Biochem       Date:  1973       Impact factor: 23.643

2.  Immunoelectrophoretic studies on glycoproteins of the human seminal plasma.

Authors:  W P Herrmann
Journal:  Arch Dermatol Forsch       Date:  1972

3.  [Immunologic analysis of tyrosinase in malignant melanoma, nevi and clinically normal skin].

Authors:  W P Herrmann
Journal:  Arch Dermatol Forsch       Date:  1971

4.  Tyrosinase as glycoprotein.

Authors:  K Miyazaki; N Otaki
Journal:  Arch Dermatol Forsch       Date:  1975
  4 in total
  2 in total

1.  [Glycoproteins: their biological and clinical significance. II (author's transl)].

Authors:  E Köttgen; C Bauer; W Reutter; W Gerok
Journal:  Klin Wochenschr       Date:  1979-03-01

2.  Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.

Authors:  M Jiménez; K Kameyama; W L Maloy; Y Tomita; V J Hearing
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205
  2 in total

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