Literature DB >> 8143348

Inhibitors of phosphatidylinositol signalling as antiproliferative agents.

G Powis1, D Phil.   

Abstract

Intracellular signalling pathways mediating the effects of oncogenes on cell growth and transformation offer novel targets for the development of anticancer drugs. With this approach it may be sufficient to target a component of the signalling pathway activated by the oncogene rather than the oncogene product itself. Phosphatidylinositol (PtdIns) is a key component of two growth factor signalling pathways. It acts as a substrate for PtdIns specific phospholipase C (PtdInsPLC) and for PtdIns-3-kinase. In this review the antiproliferative properties of some inhibitors of PtdInsPLC and PtdIns-3-kinase are considered. There are some compounds already in clinical trial as anticancer drugs that may act by inhibiting PtdIns signalling, as well as several compounds in preclinical development. Some problems that may be encountered in developing this new class of anticancer drugs are discussed.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8143348     DOI： 10.1007/bf00690420

Source DB:  PubMed          Journal:  Cancer Metastasis Rev        ISSN： 0167-7659            Impact factor:   9.264


  74 in total

1.  Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

Authors:  G Powis; M J Seewald; C Gratas; D Melder; J Riebow; E J Modest
Journal:  Cancer Res       Date:  1992-05-15       Impact factor: 12.701

2.  Inhibition of phospholipase C dependent processes by U-73, 122.

Authors:  J E Bleasdale; G L Bundy; S Bunting; F A Fitzpatrick; R M Huff; F F Sun; J E Pike
Journal:  Adv Prostaglandin Thromboxane Leukot Res       Date:  1989

Review 3.  Inositol phosphates: proliferation, metabolism and function.

Authors:  R F Irvine; R M Moor; W K Pollock; P M Smith; K A Wreggett
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1988-07-26       Impact factor: 6.237

Review 4.  Ether lipids in the therapy of cancer.

Authors:  R Andreesen
Journal:  Prog Biochem Pharmacol       Date:  1988

5.  A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF.

Authors:  J A Escobedo; L T Williams
Journal:  Nature       Date:  1988-09-01       Impact factor: 49.962

6.  Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.

Authors:  M R Smith; Y L Liu; H Kim; S G Rhee; H F Kung
Journal:  Science       Date:  1990-03-02       Impact factor: 47.728

7.  Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

Authors:  J Markovits; C Linassier; P Fossé; J Couprie; J Pierre; A Jacquemin-Sablon; J M Saucier; J B Le Pecq; A K Larsen
Journal:  Cancer Res       Date:  1989-09-15       Impact factor: 12.701

8.  Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation.

Authors:  E Peles; R Lamprecht; R Ben-Levy; E Tzahar; Y Yarden
Journal:  J Biol Chem       Date:  1992-06-15       Impact factor: 5.157

9.  Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

Authors:  D Q Wu; C H Lee; S G Rhee; M I Simon
Journal:  J Biol Chem       Date:  1992-01-25       Impact factor: 5.157

10.  Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

Authors:  E Peles; R B Levy; E Or; A Ullrich; Y Yarden
Journal:  EMBO J       Date:  1991-08       Impact factor: 11.598
View more
  5 in total

1.  Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes.

Authors:  E U Frevert; B B Kahn
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

2.  Involvement of phospholipid signal transduction pathways in morphine tolerance in mice.

Authors:  F L Smith; A B Lohmann; W L Dewey
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

3.  Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis.

Authors:  Laila Suhaiman; Gerardo A De Blas; Lina M Obeid; Alberto Darszon; Luis S Mayorga; Silvia A Belmonte
Journal:  J Biol Chem       Date:  2010-03-17       Impact factor: 5.157

4.  ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.

Authors:  Leonardo E Pelletán; Laila Suhaiman; Cintia C Vaquer; Matías A Bustos; Gerardo A De Blas; Nicolas Vitale; Luis S Mayorga; Silvia A Belmonte
Journal:  J Biol Chem       Date:  2015-02-20       Impact factor: 5.157

5.  Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth.

Authors:  Cécilia Szatkowski; Jan B Parys; Halima Ouadid-Ahidouch; Fabrice Matifat
Journal:  Mol Cancer       Date:  2010-06-21       Impact factor: 27.401
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.