Literature DB >> 8143131

Human endogenous retroviral elements and autoimmunity: data and concepts.

A Perl1, K Banki.   

Abstract

The human genome contains a complex variety of inherited endogenous retroviral sequences (ERSs), several of which are transcriptionally active and contain open reading frames. Aberrant expression of ERSs and generation of antibodies to ERS-encoded proteins have recently been revealed in autoimmune disorders. Involvement of ERSs could explain both the familial aggregation and the detection of antiretroviral antibodies in autoimmune diseases.

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Mesh：

Year:  1993        PMID： 8143131     DOI： 10.1016/0966-842x(93)90131-a

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  11 in total

Review 1.  Mechanisms of viral pathogenesis in rheumatic disease.

Authors:  A Perl
Journal:  Ann Rheum Dis       Date:  1999-08       Impact factor: 19.103

2.  Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.

Authors:  Aparna Godavarthy; Ryan Kelly; John Jimah; Miguel Beckford; Tiffany Caza; David Fernandez; Nick Huang; Manuel Duarte; Joshua Lewis; Hind J Fadel; Eric M Poeschla; Katalin Banki; Andras Perl
Journal:  JCI Insight       Date:  2020-01-16

3.  Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis.

Authors:  E Colombo; K Banki; A H Tatum; J Daucher; P Ferrante; R S Murray; P E Phillips; A Perl
Journal:  J Clin Invest       Date:  1997-03-15       Impact factor: 14.808

Review 4.  Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.

Authors:  Andras Perl
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

5.  Identification of three human sequences with viral superantigen-specific primers.

Authors:  S Indraccolo; W H Günzburg; C Leib-Mösch; V Erfle; B Salmons
Journal:  Mamm Genome       Date:  1995-05       Impact factor: 2.957

6.  Pathogenic mechanisms in systemic lupus erythematosus.

Authors:  Andras Perl
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

Review 7.  Evolution and biological significance of human retroelements.

Authors:  C Leib-Mösch; W Seifarth
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

Review 8.  Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome.

Authors:  Andras Perl
Journal:  Curr Opin Rheumatol       Date:  2009-09       Impact factor: 5.006

Review 9.  Endogenous retroviral pathogenesis in lupus.

Authors:  Andras Perl; David Fernandez; Tiffany Telarico; Paul E Phillips
Journal:  Curr Opin Rheumatol       Date:  2010-09       Impact factor: 5.006

Review 10.  Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE.

Authors:  Andras Perl; Gyorgy Nagy; Agnes Koncz; Peter Gergely; David Fernandez; Edward Doherty; Tiffany Telarico; Eduardo Bonilla; Paul E Phillips
Journal:  Autoimmunity       Date:  2008-05       Impact factor: 2.815
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