Literature DB >> 8143128

HTLV-1 Tax: regulation of gene expression and disease.

M Yoshida1.   

Abstract

The human T cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes adult T cell leukemia and the neurological disorder tropical spastic paraparesis. Pathology apparently results from the activities of the Tax protein, which trans-activates the expression of viral and cellular genes by binding to various enhancer-binding proteins needed for transcription. This ultimately results in cell transformation, immortalization and disease.

Entities:  

Mesh：

Year:  1993        PMID： 8143128     DOI： 10.1016/0966-842x(93)90127-d

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  17 in total

1.  Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb.

Authors:  C Neuveut; K G Low; F Maldarelli; I Schmitt; F Majone; R Grassmann; K T Jeang
Journal:  Mol Cell Biol       Date:  1998-06       Impact factor: 4.272

2.  Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y.

Authors:  C A Pise-Masison; J Dittmer; K E Clemens; J N Brady
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

3.  HTLV-I Tax self-association in optimal trans-activation function.

Authors:  D Y Jin; K T Jeang
Journal:  Nucleic Acids Res       Date:  1997-01-15       Impact factor: 16.971

4.  Human T cell leukaemia virus type 2 tax protein mediates CC-chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical pathway.

Authors:  C S Barrios; L Castillo; H Zhi; C-Z Giam; M A Beilke
Journal:  Clin Exp Immunol       Date:  2014-01       Impact factor: 4.330

5.  Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis.

Authors:  Weimin Wang; Jiansuo Zhou; Juan Shi; Yaxi Zhang; Shilian Liu; Yanxin Liu; Dexian Zheng
Journal:  J Virol       Date:  2013-12-18       Impact factor: 5.103

6.  Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.

Authors:  Maureen Shuh; Barry A Morse; Gisela Heidecker; David Derse
Journal:  J Virol       Date:  2011-02-23       Impact factor: 5.103

7.  CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein.

Authors:  K V Kibler; K T Jeang
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

8.  Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice.

Authors:  L Feigenbaum; K Fujita; F S Collins; G Jay
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

9.  Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Authors:  R Geleziunas; S Ferrell; X Lin; Y Mu; E T Cunningham; M Grant; M A Connelly; J E Hambor; K B Marcu; W C Greene
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

10.  Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy.

Authors:  E Wattel; J P Vartanian; C Pannetier; S Wain-Hobson
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103
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