Simultaneous measurement of the pancreatic and biliary response to CCK and secretin. Primate biliary physiology. XIII.

A primate model is described that permits separate but simultaneous sampling of both bile and pancreatic fluid without altering the normal enterohepatic circulation. Simultaneous biliary and pancreatic dose response curves are presented to contrast the production of bile with both pancreatic flow and the secretion of pancreatic protein and bicarbonate. The data show that in the cholecystectomized animal both cholecystokinin and secretin increase bile flow at doses that produce appropriate submaximal responses from the pancreas. Both these hormones, therefore, are physiologically important in regulating flow. Further, over a wide dose range (0.2 to 2.3 U per kg) secretion has the major effect on bile flow, and pancreatic flow, and pancreatic bicarbonate secretion, whereas cholyecystokinin has the major effect on pancreatic protein secretion.