Literature DB >> 813860

[DNA-intercalating compounds. Synthesis of acridine dimers].

J Barbet, B P Roques, J B Le Pecq.   

Abstract

Several alpha, omega, di(2-methoxy-6-chloro-9-acridinyl) polyaza-alkanes have been prepared starting from 6, 9-dichloro-2-methoxy acridine. Some acridine dimers are able to bind to DNA with a very high affinity, both aromatic rings being intercalated.

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Year:  1975        PMID: 813860

Source DB:  PubMed          Journal:  C R Acad Hebd Seances Acad Sci D


  1 in total

1.  Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

Authors:  Barnaby C H May; Aaron T Fafarman; Septima B Hong; Michael Rogers; Leslie W Deady; Stanley B Prusiner; Fred E Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

  1 in total

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