OBJECTIVE: To investigate the association between cigarette smoking and the progression of diabetic nephropathy. RESEARCH DESIGN AND METHODS: A prospective, follow-up study over one year was conducted in a sequential sample of 34 smokers, 35 nonsmokers, and 24 ex-smokers with type I diabetes, hypertension, and diabetic nephropathy. Progression of renal disease was defined according to the stage of nephropathy as an increase in proteinuria or serum creatinine or a decrease in the glomerular filtration rate. RESULTS: Progression of nephropathy was less common in nonsmokers (11%) than in smokers (53%) and patients who had quit smoking (33%), P < 0.001. In a stepwise logistic regression analysis, cigarette pack years, 24-h sodium excretion, and GHb were independent predictive factors for the progression of diabetic nephropathy. Because blood pressure (BP) was well controlled in these patients and most values were within a normotensive range, neither standing, sitting, nor supine BP values were associated with progression of nephropathy. CONCLUSIONS: Cigarette smoking represents an important factor associated with progression of nephropathy in treated hypertensive type I diabetic patients.
OBJECTIVE: To investigate the association between cigarette smoking and the progression of diabetic nephropathy. RESEARCH DESIGN AND METHODS: A prospective, follow-up study over one year was conducted in a sequential sample of 34 smokers, 35 nonsmokers, and 24 ex-smokers with type I diabetes, hypertension, and diabetic nephropathy. Progression of renal disease was defined according to the stage of nephropathy as an increase in proteinuria or serum creatinine or a decrease in the glomerular filtration rate. RESULTS: Progression of nephropathy was less common in nonsmokers (11%) than in smokers (53%) and patients who had quit smoking (33%), P < 0.001. In a stepwise logistic regression analysis, cigarette pack years, 24-h sodium excretion, and GHb were independent predictive factors for the progression of diabetic nephropathy. Because blood pressure (BP) was well controlled in these patients and most values were within a normotensive range, neither standing, sitting, nor supine BP values were associated with progression of nephropathy. CONCLUSIONS: Cigarette smoking represents an important factor associated with progression of nephropathy in treated hypertensive type I diabeticpatients.
Authors: Amy S Shah; Dana Dabelea; Jennifer W Talton; Elaine M Urbina; Ralph B D Agostino; R Paul Wadwa; Santica Marcovina; Richard F Hamman; Stephen R Daniels; Lawrence M Dolan Journal: J Pediatr Date: 2014-03-27 Impact factor: 4.406
Authors: Edgar A Jaimes; Ming-Sheng Zhou; Mohammed Siddiqui; Gabriel Rezonzew; Runxia Tian; Surya V Seshan; Alecia N Muwonge; Nicholas J Wong; Evren U Azeloglu; Alessia Fornoni; Sandra Merscher; Leopoldo Raij Journal: Am J Physiol Renal Physiol Date: 2021-01-18
Authors: Frederick B Dong; Stephen W Sorensen; Diane L Manninen; Theodore J Thompson; Venkat Narayan; Carlyn E Orians; Edward W Gregg; Richard C Eastman; Erik J Dasbach; William H Herman; Jeffrey M Newman; Andrew S Narva; David J Ballard; Michael M Engelgau Journal: Pharmacoeconomics Date: 2004 Impact factor: 4.981