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Literature DB >> 8135831

A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene.

F Samson¹, L Mesnard, M Mihovilovic, T G Potter, J J Mercadier, A D Roses, J R Gilbert.

Abstract

A human muscle cDNA library was screened for slow skeletal troponin T (TnTs). Sequence analysis revealed that one of the selected clones had a cDNA coding sequence different from the two previously described. RNase protection assays confirmed the expression of this new isoform in adult skeletal muscle. In addition, results of the RNase protection assays strongly suggested the expression of a fourth isoform. These isoforms for human slow TnT most likely result from combinatorial alternative splicing of a single gene.

Entities: Gene Species

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Year: 1994 PMID： 8135831 DOI： 10.1006/bbrc.1994.1305

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

13 in total

1. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.

Authors: Jose Renato Pinto; Aldrin V Gomes; Michelle A Jones; Jingsheng Liang; Susan Nguyen; Todd Miller; Michelle S Parvatiyar; James D Potter
Journal: J Biol Chem Date: 2012-09-12 Impact factor: 5.157

2. A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.

Authors: J J Johnston; R I Kelley; T O Crawford; D H Morton; R Agarwala; T Koch; A A Schäffer; C A Francomano; L G Biesecker
Journal: Am J Hum Genet Date: 2000-08-21 Impact factor: 11.025

3. Characterisation of troponin-T from salmonid fish.

Authors: D M Waddleton; D M Jackman; T Bieger; D H Heeley
Journal: J Muscle Res Cell Motil Date: 1999-04 Impact factor: 2.698

4. A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human vastus lateralis.

Authors: Jeffrey P Rabek; Charlene E Hafer-Macko; James K Amaning; James H Deford; Vincent L Dimayuga; Mark A Madsen; Richard F Macko; John Papaconstantinou
Journal: J Gerontol A Biol Sci Med Sci Date: 2009-05-15 Impact factor: 6.053

5. Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease.

Authors: Lars Larsson; Xin Wang; Fushun Yu; Peter Höök; Kristian Borg; Stephen M Chong; J-P Jin
Journal: Am J Physiol Cell Physiol Date: 2008-06-25 Impact factor: 4.249

A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene.

1. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.

2. A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.

3. Characterisation of troponin-T from salmonid fish.

4. A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human vastus lateralis.

5. Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease.

6. Comparative transcriptional and biochemical studies in muscle of myotonic dystrophies (DM1 and DM2).

Review 7. Troponin T: genetics, properties and function.

8. The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.

9. Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes.

10. Troponin T isoform expression is modulated during Atlantic halibut metamorphosis.